Mussel-Inspired Cell-Adhesion Peptide Modification for Enhanced Endothelialization of Decellularized Blood Vessels
- Authors
- Lee, Jung Seung; Lee, Kihong; Moon, Sung-Hwan; Chung, Hyung-Min; Lee, Jun Hyup; Um, Soong Ho; Kim, Dong-Ik; Cho, Seung-Woo
- Issue Date
- Aug-2014
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- cell adhesion peptide; decellularized vein matrix; endothelial progenitor cells; endothelialization; polydopamine
- Citation
- MACROMOLECULAR BIOSCIENCE, v.14, no.8, pp 1181 - 1189
- Pages
- 9
- Journal Title
- MACROMOLECULAR BIOSCIENCE
- Volume
- 14
- Number
- 8
- Start Page
- 1181
- End Page
- 1189
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69841
- DOI
- 10.1002/mabi.201400052
- ISSN
- 1616-5187
1616-5195
- Abstract
- Enhanced endothelialization of tissue-engineered blood vessels is essential for vascular regeneration and function of engineered vessels. In this study, mussel-inspired surface chemistry of polydopamine (pDA) coatings are applied to functionalize decellularized vein matrix (DVM) with extracellular matrix-derived cell adhesion peptides (RGD and YIGSR). DVMs engineered with pDA-peptides enhance focal adhesion, metabolic activity, and endothelial differentiation of human endothelial progenitor cells (EPCs) derived from cord blood and embryonic stem cells compared with EPCs on non-coated or pDA-coated DVMs. These results indicate that pDA-peptide functionalization may contribute to enhanced, rapid endothelialization of DVM surfaces by promoting adhesion, proliferation, and differentiation of circulating EPCs. Ultimately, this approach may be useful for improving in vivo patency and function of decellularized matrix-based blood vessels.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/69841)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.