Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Jungeun | - |
dc.contributor.author | Ching, Hanna | - |
dc.contributor.author | Yoon, Jeong-Kee | - |
dc.contributor.author | Jeon, Noo Li | - |
dc.contributor.author | Kim, YongTae | - |
dc.date.accessioned | 2024-01-09T06:32:18Z | - |
dc.date.available | 2024-01-09T06:32:18Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 2196-5404 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70006 | - |
dc.description.abstract | Recent developments of organoids engineering and organ-on-a-chip microfluidic technologies have enabled the recapitulation of the major functions and architectures of microscale human tissue, including tumor pathophysiology. Nevertheless, there remain challenges in recapitulating the complexity and heterogeneity of tumor microenvironment. The integration of these engineering technologies suggests a potential strategy to overcome the limitations in reconstituting the perfusable microvascular system of large-scale tumors conserving their key functional features. Here, we review the recent progress of in vitro tumor-on-a-chip microfluidic technologies, focusing on the reconstruction of microvascularized organoid models to suggest a better platform for personalized cancer medicine. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s40580-021-00261-y | - |
dc.identifier.bibliographicCitation | NANO CONVERGENCE, v.8, no.1 | - |
dc.identifier.kciid | ART002811089 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000639446100001 | - |
dc.identifier.scopusid | 2-s2.0-85104338157 | - |
dc.citation.number | 1 | - |
dc.citation.title | NANO CONVERGENCE | - |
dc.citation.volume | 8 | - |
dc.type.docType | Review | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Microfluidics | - |
dc.subject.keywordAuthor | Tumor organoids | - |
dc.subject.keywordAuthor | Microvasculature | - |
dc.subject.keywordAuthor | Organ-on-a-chip | - |
dc.subject.keywordPlus | BLOOD-BRAIN-BARRIER | - |
dc.subject.keywordPlus | IN-VITRO MODEL | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | STEM-CELL | - |
dc.subject.keywordPlus | MICROFLUIDIC PLATFORM | - |
dc.subject.keywordPlus | A-CHIP | - |
dc.subject.keywordPlus | VASCULAR NETWORKS | - |
dc.subject.keywordPlus | CAPTURES DISEASE | - |
dc.subject.keywordPlus | LARGE-SCALE | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.