Interleukin-4 Gene Transfection and Spheroid Formation Potentiate Therapeutic Efficacy of Mesenchymal Stem Cells for Osteoarthritis
DC Field | Value | Language |
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dc.contributor.author | Song, Seuk Young | - |
dc.contributor.author | Hong, Jihye | - |
dc.contributor.author | Go, Seukhyeong | - |
dc.contributor.author | Lim, Songhyun | - |
dc.contributor.author | Sohn, Hee Su | - |
dc.contributor.author | Kang, Mikyung | - |
dc.contributor.author | Jung, Gun-Jae | - |
dc.contributor.author | Yoon, Jeong-Kee | - |
dc.contributor.author | Kang, Mi Lan | - |
dc.contributor.author | Im, Gun-il | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2024-01-09T06:32:23Z | - |
dc.date.available | 2024-01-09T06:32:23Z | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2192-2640 | - |
dc.identifier.issn | 2192-2659 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70010 | - |
dc.description.abstract | Osteoarthritis (OA) is a painful intractable disease that significantly affects patients' quality of life. However, current therapies, such as pain killers and joint replacement surgery, do not lead to cartilage protection. Mesenchymal stem cells (MSCs) have been proposed as an alternative strategy for OA therapy because MSCs can secrete chondroprotective and anti-inflammatory factors. However, interleukin-4 (IL-4), a potent anti-inflammatory cytokine, is barely produced by MSCs, and MSC therapy suffers from rapid MSC death following intra-articular implantation. MSCs in spheroids survive better than naive MSCs in vitro and in vivo. IL-4-transfected MSCs in spheroids (IL-4 MSC spheroid) show increased chondroprotective and anti-inflammatory effects in an OA chondrocyte model in vitro. Following intra-articular implantation in OA rats, IL-4 MSC spheroids show better cartilage protection and pain relief than naive MSCs. Thus, IL-4 MSC spheroid may potentiate the therapeutic efficacy of MSCs for OA. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Interleukin-4 Gene Transfection and Spheroid Formation Potentiate Therapeutic Efficacy of Mesenchymal Stem Cells for Osteoarthritis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1002/adhm.201901612 | - |
dc.identifier.bibliographicCitation | ADVANCED HEALTHCARE MATERIALS, v.9, no.5 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000509007900001 | - |
dc.identifier.scopusid | 2-s2.0-85078663319 | - |
dc.citation.number | 5 | - |
dc.citation.title | ADVANCED HEALTHCARE MATERIALS | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | interleukin-4 | - |
dc.subject.keywordAuthor | mesenchymal stem cells | - |
dc.subject.keywordAuthor | osteoarthritis | - |
dc.subject.keywordAuthor | spheroids | - |
dc.subject.keywordPlus | NITRIC-OXIDE PRODUCTION | - |
dc.subject.keywordPlus | ARTICULAR-CARTILAGE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | INTRAARTICULAR INJECTION | - |
dc.subject.keywordPlus | RAT MODEL | - |
dc.subject.keywordPlus | MATRIX-METALLOPROTEINASE | - |
dc.subject.keywordPlus | CHONDROCYTE APOPTOSIS | - |
dc.subject.keywordPlus | GRAPHENE OXIDE | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | KAPPA-B | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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