Development of a Shape-Memory Tube to Prevent Vascular Stenosis
- Authors
- Shin, Yong Cheol; Lee, Jung Bok; Kim, Dae-Hyun; Kim, Taeyoung; Alexander, Grant; Shin, Young Min; Park, Ju Young; Baek, Sewoom; Yoon, Jeong-Kee; Lee, Yong Jae; Seon, Gyeung Mi; Lee, Mi Hee; Kang, Mi-Lan; Jang, Woo Soon; Park, Jong-Chul; Jun, Ho-Wook; Kim, YongTae; Sung, Hak-Joon
- Issue Date
- Oct-2019
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- computational fluid dynamics; nitric oxide-releasing peptide; shape memory polymer; vascular graft; vascular remodeling
- Citation
- ADVANCED MATERIALS, v.31, no.41
- Journal Title
- ADVANCED MATERIALS
- Volume
- 31
- Number
- 41
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70014
- DOI
- 10.1002/adma.201904476
- ISSN
- 0935-9648
1521-4095
- Abstract
- Inserting a graft into vessels with different diameters frequently causes severe damage to the host vessels. Poor flow patency is an unresolved issue in grafts, particularly those with diameters less than 6 mm, because of vessel occlusion caused by disturbed blood flow following fast clotting. Herein, successful patency in the deployment of an approximate to 2 mm diameter graft into a porcine vessel is reported. A new library of property-tunable shape-memory polymers that prevent vessel damage by expanding the graft diameter circumferentially upon implantation is presented. The polymers undergo seven consecutive cycles of strain energy-preserved shape programming. Moreover, the new graft tube, which features a diffuser shape, minimizes disturbed flow formation and prevents thrombosis because its surface is coated with nitric-oxide-releasing peptides. Improved patency in a porcine vessel for 18 d is demonstrated while occlusive vascular remodeling occurs. These insights will help advance vascular graft design.
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Collections - College of Biotechnology & Natural Resource > Department of Systems Biotechnology > 1. Journal Articles
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