Therapeutic Efficacy-Potentiated and Diseased Organ-Targeting Nanovesicles Derived from Mesenchymal Stem Cells for Spinal Cord Injury Treatment
DC Field | Value | Language |
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dc.contributor.author | Kim, Han Young | - |
dc.contributor.author | Kumar, Hemant | - |
dc.contributor.author | Jo, Min-Jae | - |
dc.contributor.author | Kim, Jonghoon | - |
dc.contributor.author | Yoon, Jeong-Kee | - |
dc.contributor.author | Lee, Ju-Ro | - |
dc.contributor.author | Kang, Mikyung | - |
dc.contributor.author | Choo, Yeon Woong | - |
dc.contributor.author | Song, Seuk Young | - |
dc.contributor.author | Kwon, Sung Pil | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Han, In-Bo | - |
dc.contributor.author | Kim, Byung-Soo | - |
dc.date.accessioned | 2024-01-09T06:32:38Z | - |
dc.date.available | 2024-01-09T06:32:38Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.issn | 1530-6992 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70020 | - |
dc.description.abstract | Human mesenchymal stem cell (hMSC)-derived exosomes have been spotlighted as a promising therapeutic agent for cell-free regenerative medicine. However, poor organ-targeting ability and insufficient therapeutic efficacy of systemically injected hMSC-exosomes were identified as critical limitations for their further applications. Therefore, in this study we fabricated iron oxide nanoparticle (IONP)-incorporated exosome-mimetic nanovesicles (NV-IONP) from IONP-treated hMSCs and evaluated their therapeutic efficacy in a clinically relevant model for spinal cord injury. Compared to exosome-mimetic nanovesicles (NV) prepared from untreated hMSCs, NV-IONP not only contained IONPs which act as a magnet-guided navigation tool but also carried greater amounts of therapeutic growth factors that can be delivered to the target cells. The increased amounts of therapeutic growth factors inside NV-IONP were attributed to IONPs that are slowly ionized to iron ions which activate the JNK and c-Jun signaling cascades in hMSCs. In vivo systemic injection of NV-IONP with magnetic guidance significantly increased the amount of NV-IONP accumulating in the injured spinal cord. Accumulated NV-IONP enhanced blood vessel formation, attenuated inflammation and apoptosis in the injured spinal cord, and consequently improved spinal cord function. Taken together, these findings highlight the development of therapeutic efficacy-potentiated extracellular nanovesicles and demonstrate their feasibility for repairing injured spinal cord. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Therapeutic Efficacy-Potentiated and Diseased Organ-Targeting Nanovesicles Derived from Mesenchymal Stem Cells for Spinal Cord Injury Treatment | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.nanolett.8b01816 | - |
dc.identifier.bibliographicCitation | NANO LETTERS, v.18, no.8, pp 4965 - 4975 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000441478300048 | - |
dc.identifier.scopusid | 2-s2.0-85049909291 | - |
dc.citation.endPage | 4975 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 4965 | - |
dc.citation.title | NANO LETTERS | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Exosomes | - |
dc.subject.keywordAuthor | iron oxide nanoparticles | - |
dc.subject.keywordAuthor | mesenchymal stem cells | - |
dc.subject.keywordAuthor | nanovesicles | - |
dc.subject.keywordAuthor | spinal cord injury | - |
dc.subject.keywordPlus | EXTRACELLULAR VESICLES | - |
dc.subject.keywordPlus | STROMAL CELLS | - |
dc.subject.keywordPlus | CONDITIONED MEDIUM | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | C-JUN | - |
dc.subject.keywordPlus | EXOSOMES | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | COMMUNICATION | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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