Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway
DC Field | Value | Language |
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dc.contributor.author | Park, Ji Hye | - |
dc.contributor.author | Son, Yang Ju | - |
dc.contributor.author | Lee, Chang Ho | - |
dc.contributor.author | Nho, Chu Won | - |
dc.contributor.author | Yoo, Gyhye | - |
dc.date.accessioned | 2024-01-09T07:34:51Z | - |
dc.date.available | 2024-01-09T07:34:51Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.issn | 2662-7671 | - |
dc.identifier.issn | 2662-7671 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70119 | - |
dc.description.abstract | Background: Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities. This study aimed to investigate the effect of Circaea mollis Siebold & Zucc on postmenopausal osteoporosis. Methods: For in vitro study, MCF7 breast cancer cells and MC3T3-E1 pre-osteoblast cells were utilized to estimate estrogenic and osteogenic activity. Osteoblastic markers were measured by western blot and real-time PCR. For in vivo study, female mature C57BL/6 mice were ovariectomized and oral administrated with 10 mg/kg and 40 mg/kg of EECM respectively. Results: EtOH extract of Circaea mollis Siebold & Zucc. (EECM) increased alkaline phosphatase activity and osteoblast marker levels at day 7 during differentiation of mouse preosteoblasts. EECM reduced osteoclast differentiation and bone resorption in an osteoblast-osteoclast primary co-culture system. In ovariectomized mice, EECM prevented the decrease in bone mineral density and recovered OSX and Runx2 via BMP2/4, Smad1/5/9 and p38. Conclusions: The results suggest that EECM may be effective in preventing bone loss, offering a promising alternative for the nutritional management of postmenopausal osteoporosis. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMC | - |
dc.title | Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s12906-020-02914-7 | - |
dc.identifier.bibliographicCitation | BMC COMPLEMENTARY MEDICINE AND THERAPIES, v.20, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000550305300001 | - |
dc.identifier.scopusid | 2-s2.0-85084268518 | - |
dc.citation.number | 1 | - |
dc.citation.title | BMC COMPLEMENTARY MEDICINE AND THERAPIES | - |
dc.citation.volume | 20 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Circaea mollis Siebold & Zucc | - |
dc.subject.keywordAuthor | Postmenopausal osteoporosis | - |
dc.subject.keywordAuthor | Osteoblast differentiation | - |
dc.subject.keywordAuthor | Runt-related transcription factor 2 | - |
dc.subject.keywordAuthor | Bone morphogenetic protein 2/4 | - |
dc.subject.keywordPlus | ESTROGEN-RECEPTOR-ALPHA | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | OSTEOBLAST | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | OSTEOCLASTS | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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