Biologically synthesis of gold nanoparticles using Cirsium japonicum var. maackii extract and the study of anti-cancer properties on AGS gastric cancer cells
DC Field | Value | Language |
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dc.contributor.author | Mi, X.-J. | - |
dc.contributor.author | Park, H.-R. | - |
dc.contributor.author | Dhandapani, S. | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.contributor.author | Kim, Y.-J. | - |
dc.date.accessioned | 2024-01-09T08:31:00Z | - |
dc.date.available | 2024-01-09T08:31:00Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1449-2288 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70146 | - |
dc.description.abstract | Plant extract-mediated synthesis of metal nanoparticles (NPs) is an eco-friendly and cost-effective biosynthesis method that is more suitable for biological applications than chemical ones. We prepared novel gold NPs (AuNPs), Cirsium japonicum mediated-AuNPs (CJ-AuNPs), using a biosynthetic process involving Cirsium japonicum (Herba Cirsii, CJ) ethanol extract. The physicochemical properties of CJ-AuNPs were characterized using spectrometric and microscopic analyses. The in vitro stability of CJ-AuNPs was studied for 3 months. Moreover, the selective human gastric adenocarcinoma (AGS) cell killing ability of CJ-AuNPs was verified in cancer and normal cells. An in vitro study revealed that CJ-AuNPs trigger oxidative stress and iron-dependent ferroptosis in AGS cells. Mechanistically, CJ-AuNPs induced mitochondrial reactive oxygen species (ROS), Fe2+, and lipid peroxidation accumulation, and mitochondrial damage by destroying the glutathione peroxidase-4 (GPX4)-dependent antioxidant capacity. Furthermore, in a xenograft mouse model implanted with AGS cells, treatment with 2.5, 5, and 10 mg/kg CJ-AuNPs for 16 days reduced tumor xenograft growth in a dose dependent manner in vivo without systemic toxicity. These results demonstrate that CJ-AuNPs exert anticancer effects in vitro and in vivo by inducing ferroptosis-mediated cancer cell death. This study, based on green-synthesized nanodrug-induced ferroptosis, provides new insight into potential developments in cancer therapies. © The author(s). | - |
dc.format.extent | 18 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Ivyspring International Publisher | - |
dc.title | Biologically synthesis of gold nanoparticles using Cirsium japonicum var. maackii extract and the study of anti-cancer properties on AGS gastric cancer cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.7150/ijbs.77734 | - |
dc.identifier.bibliographicCitation | International Journal of Biological Sciences, v.18, no.15, pp 5809 - 5826 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000862682900003 | - |
dc.identifier.scopusid | 2-s2.0-85138685173 | - |
dc.citation.endPage | 5826 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 5809 | - |
dc.citation.title | International Journal of Biological Sciences | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.publisher.location | 호주 | - |
dc.subject.keywordAuthor | Cirsium japonicum | - |
dc.subject.keywordAuthor | Ferroptosis | - |
dc.subject.keywordAuthor | Gastric cancer | - |
dc.subject.keywordAuthor | Gold nanoparticles | - |
dc.subject.keywordPlus | GREEN SYNTHESIS | - |
dc.subject.keywordPlus | FERROPTOSIS | - |
dc.subject.keywordPlus | SILVER | - |
dc.subject.keywordPlus | FLAVONOIDS | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | DC | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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