Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase
DC Field | Value | Language |
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dc.contributor.author | Wu, Xiaobin | - |
dc.contributor.author | Kim, Heejeong | - |
dc.contributor.author | Seravalli, Javier | - |
dc.contributor.author | Barycki, Joseph J. | - |
dc.contributor.author | Hart, P. John | - |
dc.contributor.author | Gohara, David W. | - |
dc.contributor.author | Di Cera, Enrico | - |
dc.contributor.author | Jung, Won Hee | - |
dc.contributor.author | Kosman, Daniel J. | - |
dc.contributor.author | Lee, Jaekwon | - |
dc.date.available | 2019-03-08T13:00:05Z | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.issn | 1083-351X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/7020 | - |
dc.description.abstract | Acquisition and distribution of metal ions support a number of biological processes. Here we show that respiratory growth of and iron acquisition by the yeast Saccharomyces cerevisiae relies on potassium (K+) compartmentalization to the trans-Golgi network via Kha1p, a K+/H+ exchanger. K+ in the trans-Golgi network facilitates binding of copper to the Fet3p multi-copper ferroxidase. The effect of K+ is not dependent on stable binding with Fet3p or alteration of the characteristics of the secretory pathway. The data suggest that K+ acts as a chemical factor in Fet3p maturation, a role similar to that of cations in folding of nucleic acids. Up-regulation of KHA1 gene in response to iron limitation via iron-specific transcription factors indicates that K+ compartmentalization is linked to cellular iron homeostasis. Our study reveals a novel functional role of K+ in the binding of copper to apoFet3p and identifies a K+/H+ exchanger at the secretory pathway as a new molecular factor associated with iron uptake in yeast. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.title | Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase | - |
dc.type | Article | - |
dc.identifier.doi | 10.1074/jbc.M115.700500 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.291, no.18, pp 9796 - 9806 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000375602300036 | - |
dc.identifier.scopusid | 2-s2.0-84994232508 | - |
dc.citation.endPage | 9806 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 9796 | - |
dc.citation.title | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 291 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | MULTICOPPER OXIDASE FET3P | - |
dc.subject.keywordPlus | UNFOLDED PROTEIN RESPONSE | - |
dc.subject.keywordPlus | VACUOLAR H+-ATPASE | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | CHLORIDE CHANNELS | - |
dc.subject.keywordPlus | GENE DELETION | - |
dc.subject.keywordPlus | DNA-BINDING | - |
dc.subject.keywordPlus | YEAST | - |
dc.subject.keywordPlus | IRON | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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