Deep Learning Assisted Target Lesion Analysis Using Advanced Border Detection Algorithm of Intravascular Ultrasound

Abstract

The vessel-plaque interface detection and lesion length of coronary artery disease are still challenging using the deep learning with intravascular ultrasound (IVUS).We used AI-based image segmentation technology to develop a deep learning model for classifying frames with IVUS-derived target lesion.Methods. A total of 3,782 target lesion frames from 28 acute coronary syndrome(ACS) patients were randomized into training and test sets in a 2:1 ratio. The training algorithm was based on the measurement of the core lab. A segmentation model using non-local blocks was used to increase the similarity between pixels of the same class in a U-Net-based model. The edge detection was performed on the region of interest, and the detected edge was used as an aid in deriving the final segmentation result. And the morphological guided measurements were used to provide the information about the vessel area, lumen area, plaque burden and lesion length. Quantitative evaluation was conducted on four scales: Jaccard Measure (JM), Dice Similarity Coefficient (DSC), Hausdorff Distance (HD), and Percentage of Area Difference (PAD). And we compared the diagnostic accuracy to detect the vessel-plaque interface of the target lesion.Results. In the training sample (1,256 IVUS frames of target lesion), and the test samples (1,072 IVUS frames of target lesion) were used for the proposed model. The external elastic membrane area (EEM), lumen area, plaque area and thrombus were assessed with the proposed algorithm. The measurement of EEM was DSC 0.99, JM 0.98, HD 0.06, and PAD 0.01. And the lumen also shows excellent performance with DSC 0.98, JM 0.97, HD 0.08, and PAD 0.01. In addition, the proposed model was compared with ground-truth for Thrombus, and showed high values of 0.88 for DSC, 0.83 for JM, 0.21 for HD, and 0.09 for PAD.Conclusion. An advanced algorithm can accurately detect the vessel-plaque interface and estimated stent length of coronary artery disease with high reproducibility. F