Preparation of phosphonated gelatin-coated titanium containing rhBMP-2 by UV irradiation for improved osteoinduction and function
DC Field | Value | Language |
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dc.contributor.author | Heo, Yun | - |
dc.contributor.author | Kim, Eun-Hye | - |
dc.contributor.author | Kobatake, Eiry | - |
dc.contributor.author | Nah, Jae-Woon | - |
dc.contributor.author | Ito, Yoshihiro | - |
dc.contributor.author | Son, Tae-Il | - |
dc.date.available | 2019-03-08T13:00:11Z | - |
dc.date.issued | 2016-04 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.issn | 1876-794X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/7026 | - |
dc.description.abstract | Gelatin derivative was prepared to coating titanium surface and photo-immobilize rhBMP-2 for improved osteoinduction and function. The conjugation was confirmed by P-31 and H-1 NMR. Photo immobilization of the azide-phosphonate-gelatin (Az-P-Gel) was evaluated by micropatterning. The rate of recombinant human bone morphogenetic protein (rhBMP-2) release was evaluated for performance of Az-P-Gel as a carrier. The water contact angle was determined to characterize Ti surface coated with Az-P-Gel. Ability to induce osteogenesis of Az-P-Gel was evaluated using alkaline phosphatase (ALP) activity assay, Alizarin Red S staining, and calcium colorimetric assay. Our results demonstrate that Ti modified with Az-P-Gel and rhBMP-2 facilitates bone regeneration. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.title | Preparation of phosphonated gelatin-coated titanium containing rhBMP-2 by UV irradiation for improved osteoinduction and function | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jiec.2016.01.006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, v.36, pp 66 - 73 | - |
dc.identifier.kciid | ART002102221 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000375815900009 | - |
dc.identifier.scopusid | 2-s2.0-84959377712 | - |
dc.citation.endPage | 73 | - |
dc.citation.startPage | 66 | - |
dc.citation.title | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.citation.volume | 36 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Gelatin | - |
dc.subject.keywordAuthor | Drug-delivery system | - |
dc.subject.keywordAuthor | Osteoinduction | - |
dc.subject.keywordAuthor | Titanium surface modification | - |
dc.subject.keywordAuthor | Photo-immobilization | - |
dc.subject.keywordPlus | BONE MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | FIBROBLAST-GROWTH-FACTOR | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | CARBOXYMETHYL CHITOSAN | - |
dc.subject.keywordPlus | MECHANICAL-PROPERTIES | - |
dc.subject.keywordPlus | IMMOBILIZATION | - |
dc.subject.keywordPlus | IMPLANTS | - |
dc.subject.keywordPlus | SURFACES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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