Fluorescence-Raman Dual Modal Endoscopic System for Multiplexed Molecular Diagnostics
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Sinyoung | - |
dc.contributor.author | Kim, Yong-il | - |
dc.contributor.author | Kang, Homan | - |
dc.contributor.author | Kim, Gunsung | - |
dc.contributor.author | Cha, Myeong Geun | - |
dc.contributor.author | Chang, Hyejin | - |
dc.contributor.author | Jung, Kyung Oh | - |
dc.contributor.author | Kim, Young-Hwa | - |
dc.contributor.author | Jun, Bong-Hyun | - |
dc.contributor.author | Hwang, Do Won | - |
dc.contributor.author | Lee, Yun-Sang | - |
dc.contributor.author | Youn, Hyewon | - |
dc.contributor.author | Lee, Yoon-Sik | - |
dc.contributor.author | Kang, Keon Wook | - |
dc.contributor.author | Lee, Dong Soo | - |
dc.contributor.author | Jeong, Dae Hong | - |
dc.date.accessioned | 2024-01-09T14:10:09Z | - |
dc.date.available | 2024-01-09T14:10:09Z | - |
dc.date.issued | 2015-03 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70385 | - |
dc.description.abstract | Optical endoscopic imaging, which was recently equipped with bioluminescence, fluorescence, and Raman scattering, allows minimally invasive real-time detection of pathologies on the surface of hollow organs. To characterize pathologic lesions in a multiplexed way, we developed a dual modal fluorescence-Raman endomicroscopic system (FRES), which used fluorescence and surface-enhanced Raman scattering nanoprobes (F-SERS dots). Real-time, in vivo, and multiple target detection of a specific cancer was successful, based on the fast imaging capability of fluorescence signals and the multiplex capability of simultaneously detected SERS signals using an optical fiber bundle for intraoperative endoscopic system. Human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR) on the breast cancer xenografts in a mouse orthotopic model were successfully detected in a multiplexed way, illustrating the potential of FRES as a molecular diagnostic instrument that enables real-time tumor characterization of receptors during routine endoscopic procedures. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Fluorescence-Raman Dual Modal Endoscopic System for Multiplexed Molecular Diagnostics | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/srep09455 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.5 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000351938500001 | - |
dc.identifier.scopusid | 2-s2.0-84926290931 | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 5 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | IN-VIVO DIAGNOSIS | - |
dc.subject.keywordPlus | CONTRAST ENHANCEMENT | - |
dc.subject.keywordPlus | NANOPARTICLE PROBES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | MICROSCOPY | - |
dc.subject.keywordPlus | ENDOMICROSCOPY | - |
dc.subject.keywordPlus | SPECTROSCOPY | - |
dc.subject.keywordPlus | SCATTERING | - |
dc.subject.keywordPlus | NEOPLASIA | - |
dc.subject.keywordPlus | GOLD | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.