Effects of Intensive Low-Salt Diet Education on Albuminuria among Nondiabetic Patients with Hypertension Treated with Olmesartan: A Single-Blinded Randomized, Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | Hwang, Jin Ho | - |
dc.contributor.author | Chin, Ho Jun | - |
dc.contributor.author | Kim, Sejoong | - |
dc.contributor.author | Kim, Dong Ki | - |
dc.contributor.author | Kim, Suhnggwon | - |
dc.contributor.author | Park, Jung Hwan | - |
dc.contributor.author | Shin, Sung Joon | - |
dc.contributor.author | Lee, Sang Ho | - |
dc.contributor.author | Choi, Bum Soon | - |
dc.contributor.author | Lim, Chun Soo | - |
dc.date.accessioned | 2024-01-09T14:32:12Z | - |
dc.date.available | 2024-01-09T14:32:12Z | - |
dc.date.issued | 2014-12 | - |
dc.identifier.issn | 1555-9041 | - |
dc.identifier.issn | 1555-905X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70423 | - |
dc.description.abstract | Background and objectives The antiproteinuric effect of a renin-angiotensin-aldosterone system blockade can be magnified by dietary salt restriction. This study sought to determine the effect of intensive low-salt diet education on BP and urine albumin excretion in nondiabetic patients with hypertension and albuminuria. Design, setting, participants, & measurements This study was conducted between March of 2012 and March of 2013 as an open-label, randomized, controlled trial. After a run-in period of 8 weeks, all patients received the angiotensin II receptor blocker olmesartan (40 mg daily). Patients were then divided into two groups. One group was treated for another 8 weeks with angiotensin II receptor blocker plus conventional low-salt diet education, and the other group was treated for 8 weeks with angiotensin II receptor blocker plus intensive low-salt diet education. The final analyses was performed with 245 completed patients. Results The amount of daily albuminuria was significantly decreased from 0 (566.0 [25.0-5398.6] mg/d) to 8 weeks (282.5 [16.1-4898.5] mg/d; P<0.001). From 8 to 16 weeks, the 24-hour urinary sodium excretion was decreased by 36.0 +/- 5.9 mmol/d in the intensive education group and 8.8 +/- 4.9 mmol/d in the conventional education group (interaction P<0.001). Patients who completed intensive low-salt diet education exhibited greater decreases in urinary albumin excretion than the control group (change in albuminuria from 8 to 16 weeks, -154.0 versus 0.4 mg/ d; P=0.01). Urinary albumin excretion tended to decrease as the 24-hour urinary sodium excretion amount decreased (R=0.32; 95% confidence interval, 0.20 to 0.43; P<0.001). Conclusions The 24-hour urinary albumin excretion was decreased more in patients in the intensive low-salt diet education group than patients in the conventional education group. Weekly intensive education on a low-salt diet would be a suitable method for clinical practice. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER SOC NEPHROLOGY | - |
dc.title | Effects of Intensive Low-Salt Diet Education on Albuminuria among Nondiabetic Patients with Hypertension Treated with Olmesartan: A Single-Blinded Randomized, Controlled Trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.2215/CJN.01310214 | - |
dc.identifier.bibliographicCitation | CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, v.9, no.12, pp 2059 - 2069 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000345947800009 | - |
dc.identifier.scopusid | 2-s2.0-84922851808 | - |
dc.citation.endPage | 2069 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2059 | - |
dc.citation.title | CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | CHRONIC KIDNEY-DISEASE | - |
dc.subject.keywordPlus | RENIN-ANGIOTENSIN SYSTEM | - |
dc.subject.keywordPlus | PATHOGENIC T(H)17 CELLS | - |
dc.subject.keywordPlus | BLOOD-PRESSURE | - |
dc.subject.keywordPlus | SODIUM RESTRICTION | - |
dc.subject.keywordPlus | ACE-INHIBITION | - |
dc.subject.keywordPlus | RENAL-FAILURE | - |
dc.subject.keywordPlus | PROTEINURIA | - |
dc.subject.keywordPlus | HYDROCHLOROTHIAZIDE | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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