Preconditioning with thyroid hormone (3,5,3-triiodothyronine) prevents renal ischemia-reperfusion injury in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Suh Min | - |
dc.contributor.author | Kim, Si-Wha | - |
dc.contributor.author | Jung, Yoo-Jun | - |
dc.contributor.author | Min, Sang-Il | - |
dc.contributor.author | Min, Seung-Kee | - |
dc.contributor.author | Kim, Sang Joon | - |
dc.contributor.author | Ha, Jongwon | - |
dc.date.accessioned | 2024-01-09T14:32:39Z | - |
dc.date.available | 2024-01-09T14:32:39Z | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 0039-6060 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70448 | - |
dc.description.abstract | Background. 3,5,3-triiodothyronine (T3) was found to decrease ischemia-reperfusion (I/R) injury of liver and myocardium in animal models when preconditioned 48 hours in advance of the I/R injury. The purpose of this study was to evaluate the effects of T3 preconditioning on renal I/R injury with different time intervals and to determine the changes in antioxidants, apoptosis, and nitric oxide synthase (NOS) in each condition. Methods. In male C57BL/6 mice, renal I/R injury was induced by temporary ligation of the bilateral renal pedicles for 45 minutes followed by a reperfusion period for 24 hours. Preconditioning with intraperitoneal injection of T3 was performed 24 or 6 hours before or at the time of I/R injury. Results. From the histologic examination, tubular injury was decreased in mice preconditioned with T3 6 hours before I/R injury. The levels of proinflammatory cytokines were decreased with T3 preconditioning, either 6 hours or at the time of I/R injury. The levels of glutathione were increased in all treatment groups. Expressions of neuronal NOS were increased when preconditioned 6 hours before or t the time of I/R injury. The number of apoptotic tubular epithelial cell evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay was decreased when preconditioned immediately before I/R injury. Conclusion. Preconditioning with T3 6 hours or immediately before I/R injury had a protective effect on renal I/R injury. The changes of NOS and antiapoptosis, other than well-known antioxidative properties, may play a.role in the effect of short-term preconditioning. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MOSBY-ELSEVIER | - |
dc.title | Preconditioning with thyroid hormone (3,5,3-triiodothyronine) prevents renal ischemia-reperfusion injury in mice | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.surg.2013.10.005 | - |
dc.identifier.bibliographicCitation | SURGERY, v.155, no.3, pp 554 - 561 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000331991200025 | - |
dc.identifier.scopusid | 2-s2.0-84894025741 | - |
dc.citation.endPage | 561 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 554 | - |
dc.citation.title | SURGERY | - |
dc.citation.volume | 155 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | NITRIC-OXIDE | - |
dc.subject.keywordPlus | ISCHEMIA/REPERFUSION INJURY | - |
dc.subject.keywordPlus | WARM ISCHEMIA | - |
dc.subject.keywordPlus | NO | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | ENDOTHELIUM | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.