Saposhnikovia divaricata root and its major components ameliorate inflammation and altered gut microbial diversity and compositions in DSS-induced colitis
DC Field | Value | Language |
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dc.contributor.author | Erdenebileg, Saruul | - |
dc.contributor.author | Son, Yang-Ju | - |
dc.contributor.author | Kim, Myungsuk | - |
dc.contributor.author | Oidovsambuu, Sarangerel | - |
dc.contributor.author | Cha, Kwang Hyun | - |
dc.contributor.author | Kwon, Jaeyoung | - |
dc.contributor.author | Jung, Da Seul | - |
dc.contributor.author | Nho, Chu Won | - |
dc.date.accessioned | 2024-01-09T14:33:14Z | - |
dc.date.available | 2024-01-09T14:33:14Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 2213-4220 | - |
dc.identifier.issn | 2213-4239 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70462 | - |
dc.description.abstract | Background: The root of Saposhnikovia divaricata (Turcz.) Schischk is a well-known traditional medicinal plant, containing various bioactive compounds with anti-inflammatory, antioxidant, and analgesic properties. However, no scientific studies have validated its clinical use as an anti-inflammatory agent against inflammatory bowel disease (IBD). This study aimed to investigate whether the root extract of S. divaricata ameliorates IBD and induces gut microbial alteration, using a RAW 264.7 cell line and a DSS-induced colitis mouse model. Methods: To investigate the anti-inflammatory effects and alleviation of IBD, using a methanol extract of Saposhnikovia divaricata (Turcz.) Schischk. root (MESD), RAW 264.7, murine macrophages and a dextran sodium sulfate (DSS)-induced colitis mouse model were employed. 16S rRNA gene sequencing was conducted to determine the alterations in the gut microbiota of mice with DSS-induced colitis. Results: MESD significantly decreased nitric oxide (NO) and inflammatory cytokine levels in lipopolysaccharide (LPS)-induced RAW 264.7 cells in vitro. Oral administration of MESD reduced the expression of inflammatory cytokines in the colons of mice with DSS-induced colitis. Additionally, MESD inhibited the abundance of Clostridium sensu stricto 1 and enhanced the predicted functional pathways, including L-glutamate degradation VIII (to propanoic acid). Seven compounds with anti-inflammatory properties were isolated from the MESD. Among them, 3′-O-acetylhamaudol and 3′-O-angeloylhamaudol exhibited strong anti-inflammatory effects in vitro. Conclusion: Overall, MESD may be a potential natural product for the treatment of IBD by lowering inflammatory cytokine levels and altering gut microbiota composition. © 2023 | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Korea Institute of Oriental Medicine | - |
dc.title | Saposhnikovia divaricata root and its major components ameliorate inflammation and altered gut microbial diversity and compositions in DSS-induced colitis | - |
dc.title.alternative | Saposhnikovia divaricata root and its major components ameliorate inflammation and altered gut microbial diversity and compositions in DSS-induced colitis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.imr.2023.100998 | - |
dc.identifier.bibliographicCitation | Integrative Medicine Research, v.12, no.4, pp 1 - 12 | - |
dc.identifier.kciid | ART003022724 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001108619000001 | - |
dc.identifier.scopusid | 2-s2.0-85175210141 | - |
dc.citation.endPage | 12 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | Integrative Medicine Research | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | DSS-induced colitis | - |
dc.subject.keywordAuthor | Gut microbiota | - |
dc.subject.keywordAuthor | Inflammatory bowel disease | - |
dc.subject.keywordAuthor | Inflammatory response | - |
dc.subject.keywordAuthor | Saposhnikovia divaricata | - |
dc.subject.keywordPlus | PERFORMANCE LIQUID-CHROMATOGRAPHY | - |
dc.subject.keywordPlus | O-GLUCOSYLCIMIFUGIN | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | PROBIOTICS | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | ENZYMES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | IBD | - |
dc.relation.journalResearchArea | Integrative & Complementary Medicine | - |
dc.relation.journalWebOfScienceCategory | Integrative & Complementary Medicine | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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