A Review and Update on Papillary Immature Metaplasia of the Uterine Cervix A Distinct Subset of Low-Grade Squamous Intraepithelial Lesion, Proposing a Possible Cell of Origin
DC Field | Value | Language |
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dc.contributor.author | Hong, Soon Auck | - |
dc.contributor.author | Yoo, Su Hyun | - |
dc.contributor.author | Choi, Jene | - |
dc.contributor.author | Robboy, Stanley J. | - |
dc.contributor.author | Kim, Kyu-Rae | - |
dc.date.accessioned | 2024-01-09T14:36:27Z | - |
dc.date.available | 2024-01-09T14:36:27Z | - |
dc.date.issued | 2018-08 | - |
dc.identifier.issn | 0003-9985 | - |
dc.identifier.issn | 1543-2165 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70513 | - |
dc.description.abstract | Context.-Papillary immature metaplasia (PIM) is a known papillary cervical lesion associated with low-risk human papillomavirus (LR-HPV). Objective.-To evaluate additional clinicopathologic features and the HPV genotypes of PIM and discuss the presumptive cell of origin. Design.-A total of 26 PIM cases were evaluated by p16(INK4a), cytokeratin (CK) 7, and CK17 immunohistochemical stainings. Human papillomavirus genotyping was performed, by using HPV DNA Chip, HPV polymerase chain reaction (PCR), and real-time PCR. Results.-Histologically, PIM forms either a papillary mass (n = 21 of 26, 81%) or a slightly elevated/flat plaque (n = 5, 19%). All cases contain variable amounts of mucinous epithelia within the lesions. Koilocytosis was identified in 15 of the 26 cases (58%). Sixteen cases (61%) were associated with LR-HPV (types 6, 11, or 42), but 3 cases (12%) with high-risk (HR) HPV (16, 16/18, and 33), 2 cases (8%) with mixed LR- and HR-HPV (6/16 and 11/58), while 2 cases (8%) were negative, but p16INK4a immuno-staining showed nonblock positivity in all cases. Eight (31%) had high-grade squamous intraepithelial lesion (HSIL) in the adjacent mucosa, 4 (50%) of which showed direct continuity. Identical HPV subtypes were confirmed in separately microdissected cases from PIM and adjacent HSIL. Most lesions (n = 24, 92%) expressed CK17 (reserve cell marker) in a bottom-heavy pattern and CK7 (squamocolumnar junction [SCJ] marker) in a top-heavy pattern, while most cases of low-grade squamous intraepithelial lesion (LSIL) were negative for both markers. Conclusions.-Our results suggest that PIM is a distinct subset of LSIL showing a productive HPV infection, but PIM involves the transformation zone and is proximal to SCJ, while LSIL is mostly from ectocervix or distal to the SCJ. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | COLL AMER PATHOLOGISTS | - |
dc.title | A Review and Update on Papillary Immature Metaplasia of the Uterine Cervix A Distinct Subset of Low-Grade Squamous Intraepithelial Lesion, Proposing a Possible Cell of Origin | - |
dc.type | Article | - |
dc.identifier.doi | 10.5858/arpa.2017-0267-OA | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, v.142, no.8, pp 973 - 981 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000439572700015 | - |
dc.identifier.scopusid | 2-s2.0-85052379330 | - |
dc.citation.endPage | 981 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 973 | - |
dc.citation.title | ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE | - |
dc.citation.volume | 142 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | SQUAMOCOLUMNAR JUNCTION | - |
dc.subject.keywordPlus | CONDYLOMA | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | LIFE | - |
dc.relation.journalResearchArea | Medical Laboratory Technology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Medical Laboratory Technology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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