Expression of Programmed Death Receptor Ligand 1 with High Tumor Infiltrating Lymphocytes Is Associated with Better Prognosis in Breast Cancer
DC Field | Value | Language |
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dc.contributor.author | Bae, Sang Byung | - |
dc.contributor.author | Cho, Hyun Deuk | - |
dc.contributor.author | Oh, Mee-Hye | - |
dc.contributor.author | Lee, Ji-Hye | - |
dc.contributor.author | Jang, Si-Hyong | - |
dc.contributor.author | Hong, Soon Auck | - |
dc.contributor.author | Cho, Junhun | - |
dc.contributor.author | Kim, Sung Yong | - |
dc.contributor.author | Han, Sun Wook | - |
dc.contributor.author | Lee, Jong Eun | - |
dc.contributor.author | Kim, Han Jo | - |
dc.contributor.author | Lee, Hyun Ju | - |
dc.date.accessioned | 2024-01-09T14:36:51Z | - |
dc.date.available | 2024-01-09T14:36:51Z | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 1738-6756 | - |
dc.identifier.issn | 2092-9900 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70535 | - |
dc.description.abstract | Purpose: The interaction of programmed death receptor 1 (PD-1) and its ligand, programmed death receptor ligand 1 (PD-L1), negatively regulates immune responses. This study aimed to clarify PD-L1 expression levels in breast cancer through immunohistochemistry (IHC) and to evaluate associations between these findings and clinicopathologic variables, including prognosis. Methods: PD-L1 expression was analyzed using IHC on tissue microarrays of 465 invasive breast carcinomas. Results: High PD-L1 expression was demonstrated in 63 of 465 tumors (13.5%). High PD-L1 expression was significantly associated with high histologic grade (p<0.001), negative lymph nodes (p=0.011), early pathologic stage (p=0.025), high tumor-infiltrating lymphocyte (TIL) (p<0.001) counts, negative estrogen receptor (p<0.001) and progesterone receptor (p=0.002) expression, positive human epidermal growth factor receptor 2 (HER2) (p=0.003), cytokeratin 5/6 (p=0.011), epidermal growth factor receptor (p<0.001), and p53 (p<0.001) expression, and high Ki-67 proliferating index (p<0.001). Based on intrinsic subtypes, high PD-L1 expression and high TIL counts were significantly associated with the HER2 and triple-negative basal type (p<0.001). PD-L1 expression was significantly associated with better disease-free survival (DFS) (p=0.041) and overall survival (OS) (p=0.026) in the univariate analysis, but not in the multivariate analysis. Higher TIL levels was an independent prognostic factor for decreased disease progression (hazard ratio [HR], 2.389; 95% confidence interval [CI], 1.284-4.445; p=0.006) and overall death (HR, 3.666; 95% CI, 1.561-8.607; p=0.003). Conclusion: PD-L1 protein expression in breast cancer is associated with better DFS and OS, but is not an independent prognostic factor. High PD-L1 expression was significantly associated with high TIL levels. This finding has important implications for antibody therapies targeting the PD-1/PD-L1 signaling mechanism in breast cancer. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN BREAST CANCER SOC | - |
dc.title | Expression of Programmed Death Receptor Ligand 1 with High Tumor Infiltrating Lymphocytes Is Associated with Better Prognosis in Breast Cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.4048/jbc.2016.19.3.242 | - |
dc.identifier.bibliographicCitation | JOURNAL OF BREAST CANCER, v.19, no.3, pp 242 - 251 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000384386800003 | - |
dc.identifier.scopusid | 2-s2.0-84992034904 | - |
dc.citation.endPage | 251 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 242 | - |
dc.citation.title | JOURNAL OF BREAST CANCER | - |
dc.citation.volume | 19 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Breast neoplasms | - |
dc.subject.keywordAuthor | PD-L1 | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordAuthor | Tumor-infiltrating lymphocytes | - |
dc.subject.keywordPlus | PD-L1 EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN EXPRESSION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | B7-H1 | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordPlus | TOLERANCE | - |
dc.subject.keywordPlus | POOR | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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