The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | He, Shizhi | - |
dc.contributor.author | He, Shuangba | - |
dc.contributor.author | Chen, Chun-Hao | - |
dc.contributor.author | Deborde, Sylvie | - |
dc.contributor.author | Bakst, Richard L | - |
dc.contributor.author | Chernichenko, Natalya | - |
dc.contributor.author | McNamara, William F | - |
dc.contributor.author | Lee, Sei Young | - |
dc.contributor.author | Barajas, Fernando | - |
dc.contributor.author | Yu, Zhenkun | - |
dc.contributor.author | Al-Ahmadie, Hikmat A | - |
dc.contributor.author | Wong, Richard J | - |
dc.date.accessioned | 2024-01-09T15:01:36Z | - |
dc.date.available | 2024-01-09T15:01:36Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 1541-7786 | - |
dc.identifier.issn | 1557-3125 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70575 | - |
dc.description.abstract | Perineural invasion is a form of cancer progression where cancer cells invade along nerves. This behavior is associated with poor clinical outcomes; therefore, it is critical to identify novel ligand-receptor interactions between nerves and cancer cells that support the process of perineural invasion. A proteomic profiler chemokine array was used to screen for nerve-derived factors secreted from tissue explants of dorsal root ganglion (DRG), and CCL2 was identified as a lead candidate. Prostate cancer cell line expression of CCR2, the receptor to CCL2, correlated closely with MAPK and Akt pathway activity and cell migration towards CCL2 and DRG. In vitro nerve and cancer coculture invasion assays of perineural invasion demonstrated that cancer cell CCR2 expression facilitates perineural invasion. Perineural invasion is significantly diminished in coculture assays when using DRG harvested from CCL2(-/-) knockout mice as compared with control CCL2(+/+) mice, indicating that CCR2 is required for perineural invasion in this murine model of perineural invasion. Furthermore, 20 of 21 (95%) patient specimens of prostate adenocarcinoma with perineural invasion exhibited CCR2 expression by immunohistochemistry, while just 3 of 13 (23%) lacking perineural invasion expressed CCR2. In summary, nerve-released CCL2 supports prostate cancer migration and perineural invasion though CCR2-mediated signaling. CONCLUSIONS: These results reveal CCL2-CCR2 signaling as a key ligand-receptor mechanism that mediates cancer cell communication with nerves during perineural invasion and highlight a potential future therapeutic target. ©2014 American Association for Cancer Research. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | The chemokine (CCL2-CCR2) signaling axis mediates perineural invasion | - |
dc.type | Article | - |
dc.identifier.doi | 10.1158/1541-7786.MCR-14-0303 | - |
dc.identifier.bibliographicCitation | Molecular cancer research : MCR, v.13, no.2, pp 380 - 390 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 390 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 380 | - |
dc.citation.title | Molecular cancer research : MCR | - |
dc.citation.volume | 13 | - |
dc.type.docType | Journal Article;Research Support, N.I.H., Extramural;Research Support, Non-U.S. Gov't | - |
dc.publisher.location | 미국 | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.