Acute lymphoblastic leukemia secondary to chemoradiotherapy for perivascular epithelioid cell tumor of uterus
- Authors
- Jeon, In-sang; Yi, Dae Yong
- Issue Date
- Mar-2009
- Keywords
- Anthracycline; Perivascular epithelioid tumor; Secondary leukemia
- Citation
- Pediatric Hematology and Oncology, v.26, no.2, pp 120 - 123
- Pages
- 4
- Journal Title
- Pediatric Hematology and Oncology
- Volume
- 26
- Number
- 2
- Start Page
- 120
- End Page
- 123
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70593
- DOI
- 10.1080/08880010902754859
- ISSN
- 0888-0018
1521-0669
- Abstract
- Acute lymphoblastic leukemia (ALL), a primary hematologic malignancy that is especially common in childhood, occurs relatively rarely as a secondary malignant neoplasm. Available data indicate that ALL often follows chemoradiotherapy for soft tissue sarcoma. Perivascular epithelioid tumor (PEComa), a primitive mesenchymal tissue origin, can be classified as a soft tissue sarcoma. An 11-year-old girl was diagnosed with ALL secondary to chemoradiotherapy (vincristine, ifosfamide, and anthracycline) and radiotherapy comprising 45 Gy to the whole pelvis for PEComa. ALL, FAB L2, and immunophenotypically pro-B developed 16 months after the final chemotherapy treatment. Moreover, a cytogenetic study of lymphoblasts showed t(1;11)(p32;q23). Herein, the authors report a case of secondary ALL that might be related to a previously used intercalating DNA topoisomerase II inhibitor (anthracycline) for a very rare sarcoma, PEComa.
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