Relationship between polymorphisms near the IL28B gene and spontaneous HBsAg seroclearance: a systematic review and meta-analysis
DC Field | Value | Language |
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dc.contributor.author | Lee, D. H. | - |
dc.contributor.author | Lee, J. -H. | - |
dc.contributor.author | Kim, Y. J. | - |
dc.contributor.author | Park, N. H. | - |
dc.contributor.author | Cho, Y. | - |
dc.contributor.author | Lee, Y. B. | - |
dc.contributor.author | Yoo, J. -J. | - |
dc.contributor.author | Lee, M. | - |
dc.contributor.author | Cho, Y. Y. | - |
dc.contributor.author | Choi, W. -M. | - |
dc.contributor.author | Yu, S. J. | - |
dc.contributor.author | Yoon, J. -H. | - |
dc.contributor.author | Kim, C. Y. | - |
dc.contributor.author | Lee, H. -S. | - |
dc.date.accessioned | 2024-01-09T17:02:58Z | - |
dc.date.available | 2024-01-09T17:02:58Z | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 1352-0504 | - |
dc.identifier.issn | 1365-2893 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70848 | - |
dc.description.abstract | Polymorphisms near the interleukin (IL) 28B gene have been proposed to be associated with spontaneous clearance of the hepatitis C virus. The purpose of this study was to assess the relationship between IL28B polymorphisms and the rate of spontaneous hepatitis B surface antigen (HBsAg) seroclearance by means of meta-analysis. MEDLINE/PubMed and EMBASE were utilized to identify relevant studies. Odds ratio (OR) and 95% confidence interval (CI) were analysed together to assess the strength of the association. Subgroup analyses were mainly performed according to ethnicity. A total of 4028 cases with persistent chronic hepatitis B and 2327 spontaneously recovered controls were included from 11 studies. The single nucleotide polymorphism (SNP), rs12979860, had no significant association with HBsAg seroclearance (OR=0.98, 95% CI: 0.84-1.14 in the dominant model; OR=1.00, 95% CI: 0.68-1.46 in the recessive model; and OR=0.95, 95% CI: 0.82-1.09 in the allelic model). The SNP, rs12980275, had no significant association either (OR=1.03, 95% CI: 0.84-1.26 in the dominant model; OR=1.17, 95% CI: 0.46-2.96 in the recessive model; and OR=1.04, 95% CI: 0.86-1.26 in the allelic model), nor did the SNP, rs8099917 (OR=0.94, 95% CI: 0.77-1.15 in the dominant model; OR=0.74, 95% CI: 0.34-1.62 in the recessive model; and OR=0.93, 95% CI: 0.77-1.13 in the allelic model). Similarly, the results of subgroup analyses by ethnicity also showed no association in either the Asian group or non-Asian group. We concluded that there was no significant association between common IL28B polymorphisms and the rate of spontaneous HBsAg seroclearance. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Relationship between polymorphisms near the IL28B gene and spontaneous HBsAg seroclearance: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/jvh.12193 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VIRAL HEPATITIS, v.21, no.3, pp 163 - 170 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000329816600002 | - |
dc.identifier.scopusid | 2-s2.0-84892823295 | - |
dc.citation.endPage | 170 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 163 | - |
dc.citation.title | JOURNAL OF VIRAL HEPATITIS | - |
dc.citation.volume | 21 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | hepatitis B surface antigen | - |
dc.subject.keywordAuthor | hepatitis B virus | - |
dc.subject.keywordAuthor | interleukin 28B | - |
dc.subject.keywordAuthor | meta-analysis | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordPlus | HEPATITIS-B-VIRUS | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | PUTATIVE ASSOCIATION | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | INTERFERON-ALPHA | - |
dc.subject.keywordPlus | INTERLEUKIN 28B | - |
dc.subject.keywordPlus | IFN-LAMBDA | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INFECTION | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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