Anterior Cervical Discectomy and Fusion Performed Using a CaO-SiO2-P2O5-B2O3 Bioactive Glass Ceramic or Polyetheretherketone Cage Filled with Hydroxyapatite/& beta;-Tricalcium Phosphate: A Prospective Randomized Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | Park, Jiwon | - |
dc.contributor.author | Park, Sang-Min | - |
dc.contributor.author | Ham, Dae-Woong | - |
dc.contributor.author | Hong, Jae-Young | - |
dc.contributor.author | Kim, Ho-Joong | - |
dc.contributor.author | Yeom, Jin S. | - |
dc.date.accessioned | 2024-01-09T17:34:19Z | - |
dc.date.available | 2024-01-09T17:34:19Z | - |
dc.date.issued | 2023-06 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70891 | - |
dc.description.abstract | A CaO-SiO2-P2O5-B2O3 bioactive glass-ceramic (BGS-7) spacer provides high mechanical stability, produces a chemical bond to the adjacent endplate, and facilitates fusion after spine surgery. This prospective, randomized, single-blind, non-inferiority trial aimed to evaluate the radiographic outcomes and clinical efficacy of anterior cervical discectomy and fusion (ACDF) using a BGS-7 spacer for treating cervical degenerative disorders. Thirty-six patients underwent ACDF using a BGS-7 spacer (Group N), and 40 patients underwent ACDF using polyetheretherketone (PEEK) cages filled with a mixture of hydroxyapatite (HA) and & beta;-tricalcium phosphate (& beta;-TCP) for the treatment of cervical degenerative disorders. The spinal fusion rate was assessed 12 months postoperatively using three-dimensional computed tomography (CT) and dynamic radiographs. Clinical outcomes included patient-reported outcome measures, visual analog scale scores for neck and arm pain, and scores from the neck disability index (NDI), European Quality of Life-5 Dimensions (EQ-5D), and 12-item Short Form Survey (SF-12v2). All participants were randomly assigned to undergo ACDF using either a BGS-7 spacer or PEEK cage filled with HA and & beta;-TCP. The primary outcome was the fusion rate on CT scan image at 12 months after ACDF surgery based on a per-protocol strategy. Clinical outcomes and adverse events were also assessed. The 12-month fusion rates for the BGS-7 and PEEK groups based on CT scans were 81.8% and 74.4%, respectively, while those based on dynamic radiographs were 78.1% and 73.7%, respectively, with no significant difference between the groups. There were no significant differences in the clinical outcomes between the two groups. Neck pain, arm pain, NDI, EQ-5D, and SF-12v2 scores significantly improved postoperatively, with no significant differences between the groups. No adverse events were observed in either group. In ACDF surgery, the BGS-7 spacer showed similar fusion rates and clinical outcomes as PEEK cages filled with HA and & beta;-TCP. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | Anterior Cervical Discectomy and Fusion Performed Using a CaO-SiO2-P2O5-B2O3 Bioactive Glass Ceramic or Polyetheretherketone Cage Filled with Hydroxyapatite/& beta;-Tricalcium Phosphate: A Prospective Randomized Controlled Trial | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/jcm12124069 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.12, no.12 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001014494200001 | - |
dc.identifier.scopusid | 2-s2.0-85164034265 | - |
dc.citation.number | 12 | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 스위스 | - |
dc.subject.keywordAuthor | ACDF | - |
dc.subject.keywordAuthor | cervical | - |
dc.subject.keywordAuthor | fusion rate | - |
dc.subject.keywordAuthor | glass ceramics | - |
dc.subject.keywordAuthor | PEEK cage | - |
dc.subject.keywordPlus | INTERBODY FUSION | - |
dc.subject.keywordPlus | BGS-7 | - |
dc.subject.keywordPlus | ALLOGRAFT | - |
dc.subject.keywordPlus | SPACER | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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