Reappraising the clinical usability of consolidation-to-tumor ratio on CT in clinical stage IA lung cancer
DC Field | Value | Language |
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dc.contributor.author | Yoon, Dong Woog | - |
dc.contributor.author | Kim, Chu Hyun | - |
dc.contributor.author | Hwang, Soohyun | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Cho, Jong Ho | - |
dc.contributor.author | Kim, Hong Kwan | - |
dc.contributor.author | Choi, Yong Soo | - |
dc.contributor.author | Kim, Jhingook | - |
dc.contributor.author | Shim, Young Mog | - |
dc.contributor.author | Shin, Sumin | - |
dc.contributor.author | Lee, Ho Yun | - |
dc.date.accessioned | 2024-01-10T07:00:26Z | - |
dc.date.available | 2024-01-10T07:00:26Z | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 1869-4101 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70923 | - |
dc.description.abstract | Objectives Ground-glass opacity (GGO) on computed tomography is associated with prognosis in early-stage non-small cell lung cancer (NSCLC) patients. However, the stratification of the prognostic value of GGO is controversial. We aimed to evaluate clinicopathologic characteristics of early-stage NSCLC based on the consolidation-to-tumor ratio (CTR), conduct multi-pronged analysis, and stratify prognosis accordingly. Methods We retrospectively investigated 944 patients with clinical stage IA NSCLC, who underwent curative-intent lung resection between August 2018 and January 2020. The CTR was measured and used to categorize patients into six groups (1, 0%; 2, 0-25%; 3, 25-50%; 4, 50-75%; 5, 75-100%; and 6, 100%). Results Pathologic nodal upstaging was found in 1.8% (group 4), 9.0% (group 5), and 17.4% (group 6), respectively. The proportion of patients with a high grade of tumor-infiltrating lymphocytes tended to decrease as the CTR increased. In a subtype analysis of patients with adenocarcinoma, all of the patients with predominant micro-papillary patterns were in the CTR > 50% groups, and most of the patients with predominant solid patterns were in group 6 (47/50, 94%). The multivariate analysis demonstrated that CTR 75-100% (hazard ratio [HR], 3.85; 95% confidence interval [CI], 1.58-9.36) and CTR 100% (HR, 5.58; 95% CI, 2.45-12.72) were independent prognostic factors for DFS, regardless of tumor size. Conclusion We demonstrated that the CTR could provide various noninvasive clinicopathological information. A CTR of more than 75% is the factor associated with a poor prognosis and should be considered when making therapeutic plans for patients with early-stage NSCLC. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Reappraising the clinical usability of consolidation-to-tumor ratio on CT in clinical stage IA lung cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1186/s13244-022-01235-2 | - |
dc.identifier.bibliographicCitation | INSIGHTS INTO IMAGING, v.13, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000812508300001 | - |
dc.identifier.scopusid | 2-s2.0-85132106098 | - |
dc.citation.number | 1 | - |
dc.citation.title | INSIGHTS INTO IMAGING | - |
dc.citation.volume | 13 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Lung cancer | - |
dc.subject.keywordAuthor | Ground-glass opacity | - |
dc.subject.keywordAuthor | Consolidation-to-tumor ratio | - |
dc.subject.keywordAuthor | Prognosis | - |
dc.subject.keywordPlus | FORTHCOMING 8TH EDITION | - |
dc.subject.keywordPlus | TNM CLASSIFICATION | - |
dc.subject.keywordPlus | PROJECT PROPOSALS | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | MICROPAPILLARY | - |
dc.subject.keywordPlus | GROUPINGS | - |
dc.subject.keywordPlus | RESECTION | - |
dc.subject.keywordPlus | REVISION | - |
dc.subject.keywordPlus | PATTERN | - |
dc.subject.keywordPlus | IMPACT | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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