Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Immune Responses against the Omicron Variant of SARS-CoV-2 after a Third Dose of COVID-19 Vaccine in Patients Living with Human Immunodeficiency Virus (PLWH): Comparison with Healthcare Workers

Full metadata record
DC Field Value Language
dc.contributor.authorPark, Joung Ha-
dc.contributor.authorChung, Hyemin-
dc.contributor.authorKim, Min-Chul-
dc.contributor.authorChoi, Seong-Ho-
dc.contributor.authorChung, Jin-Won-
dc.date.accessioned2024-01-10T08:30:59Z-
dc.date.available2024-01-10T08:30:59Z-
dc.date.issued2022-12-
dc.identifier.issn2076-393X-
dc.identifier.issn2076-393X-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70942-
dc.description.abstractWe compared immune responses against the omicron variant of SARS-CoV-2 after a third dose of the coronavirus disease 2019 (COVID-19) vaccine between people living with human immunodeficiency (PLWH) and healthcare workers (HCWs). In this prospective observational study, PLWH and HCWs vaccinated with at least two doses of vaccine were enrolled. We analyzed neutralizing responses using the GenScript SARS-CoV-2 surrogate virus neutralization test kit. Twenty-nine PLWH and 114 HCWs were included to analyze immune responses after the third vaccination. Most PLWH (86.2%) had fully suppressed viral loads and CD4 T cell counts were well-controlled (median 670.0 cells/μL). The neutralizing responses against the omicron variant in PLWH were not significantly different from those in HCWs (43.94% vs. 51.77%, p = 0.42). However, neutralizing responses against the omicron variant were significantly impaired by about 50% compared with wild type SARS-CoV-2 in PLWH (43.94% vs. 97.46%, p < 0.001) and HCWs (51.77% vs. 97.74%, p < 0.001). Although neutralizing responses against the omicron variant in well-controlled PLWH were comparable to those of HCWs, the responses were much lower than those against wild type in both PLWH and HCWs. Therefore, the risk of breakthrough SARS-CoV-2 infection due to the currently circulating omicron variant is still high despite three doses of vaccine in PLWH and will not differ from HCWs. © 2022 by the authors.-
dc.language영어-
dc.language.isoENG-
dc.publisherMDPI-
dc.titleImmune Responses against the Omicron Variant of SARS-CoV-2 after a Third Dose of COVID-19 Vaccine in Patients Living with Human Immunodeficiency Virus (PLWH): Comparison with Healthcare Workers-
dc.typeArticle-
dc.identifier.doi10.3390/vaccines10122129-
dc.identifier.bibliographicCitationVaccines, v.10, no.12-
dc.description.isOpenAccessY-
dc.identifier.wosid000904533200001-
dc.identifier.scopusid2-s2.0-85144686889-
dc.citation.number12-
dc.citation.titleVaccines-
dc.citation.volume10-
dc.type.docTypeArticle-
dc.publisher.location스위스-
dc.subject.keywordAuthorcellular immunity-
dc.subject.keywordAuthorhealth personnel-
dc.subject.keywordAuthorhumoral immunity-
dc.subject.keywordAuthoromicron-
dc.subject.keywordAuthorpatient living with HIV (PLWH)-
dc.subject.keywordAuthorSARS-CoV-2-
dc.subject.keywordPlusHIV-INFECTION-
dc.relation.journalResearchAreaImmunology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Files in This Item
Appears in
Collections
ETC > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Choi, Seong Ho photo

Choi, Seong Ho
의과대학 (의학부(임상-서울))
Read more

Altmetrics

Total Views & Downloads

BROWSE