Dichotomous versus 5-scale grading system for the interpretation of the point-of-care immunoassay for tear matrix metalloproteinase-9 in dry eye
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Ja Young | - |
dc.contributor.author | Chun, Yeoun Sook | - |
dc.contributor.author | Kim, Kyoung Woo | - |
dc.date.accessioned | 2024-01-11T02:01:17Z | - |
dc.date.available | 2024-01-11T02:01:17Z | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70947 | - |
dc.description.abstract | In this study, we compared the dichotomous and 5-scale grading systems for point-of-care immunoassay of tear matrix metalloproteinase (MMP)-9 in dry eye disease (DED) patients and identified the optimal dichotomous system to correlate with DED parameters. We included 167 DED patients without primary Sjogren's syndrome (pSS) (Non-SS DED) and 70 DED patients with pSS (SS DED). We graded MMP-9 expression in InflammaDry® (Quidel, San Diego, CA, USA) using a 5-scale grading system and dichotomous grading systems with four different cut-off grades (D1 to D4 systems). The only DED parameter that showed a significant correlation with the 5-scale grading method was tear osmolarity (Tosm). In both groups, subjects with positive MMP-9 had lower tear secretion and higher Tosm than those with negative MMP-9 according to the D2 dichotomous system. Tosm determined D2 positivity at cutoffs > 340.5 and > 317.5 mOsm/L in the Non-SS DED and SS DED groups, respectively. Tear secretion < 10.5 mm or tear break-up time < 5.5 s stratified D2 positivity in the Non-SS DED group. In conclusion, the dichotomous grading system of InflammaDry reflects ocular surface indices better than the 5-scale grading system and may be more practical in real clinical circumstances. © 2023. The Author(s). | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NLM (Medline) | - |
dc.title | Dichotomous versus 5-scale grading system for the interpretation of the point-of-care immunoassay for tear matrix metalloproteinase-9 in dry eye | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41598-023-32928-3 | - |
dc.identifier.bibliographicCitation | Scientific reports, v.13, no.1 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000984454500087 | - |
dc.identifier.scopusid | 2-s2.0-85152473508 | - |
dc.citation.number | 1 | - |
dc.citation.title | Scientific reports | - |
dc.citation.volume | 13 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordPlus | OCULAR SURFACE | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | DOXYCYCLINE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MMP-9 | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.