Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKCδ activation in the hippocampus of mice: Involvement of antioxidant potential
DC Field | Value | Language |
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dc.contributor.author | Tran, Ngoc Kim Cuong | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Sharma, Naveen | - |
dc.contributor.author | Nguyen, Yen Nhi Doan | - |
dc.contributor.author | Tran, Hoang-Yen Phi | - |
dc.contributor.author | Dang, Duy-Khanh | - |
dc.contributor.author | Park, Jung Hoon | - |
dc.contributor.author | Byun, Jae Kyung | - |
dc.contributor.author | Jin, Dezhong | - |
dc.contributor.author | Xiaoyan, Zeng | - |
dc.contributor.author | Ko, Sung Kwon | - |
dc.contributor.author | Nah, Seung-Yeol | - |
dc.contributor.author | Kim, Hyoung-Chun | - |
dc.contributor.author | Shin, Eun-Joo | - |
dc.date.accessioned | 2024-01-17T05:00:34Z | - |
dc.date.available | 2024-01-17T05:00:34Z | - |
dc.date.issued | 2023-08 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.issn | 1873-6351 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/70994 | - |
dc.description.abstract | Although the anticonvulsant effects of ginsenosides are recognized, little is known about their effects on the convulsive behaviors induced by the activation of L-type Ca2+ channels. Here, we investigated whether ginsenoside Re (GRe) modulates excitotoxicity induced by the L-type Ca2+ channel activator Bay k-8644. GRe significantly attenuated Bay k-8644-induced convulsive behaviors and hippocampal oxidative stress in mice. GRe-mediated antioxidant potential was more pronounced in the mitochondrial fraction than cytosolic fraction. As L-type Ca2+ channels are thought to be targets of protein kinase C (PKC), we investigated the role of PKC under excitotoxic conditions. GRe attenuated Bay k-8644-induced mitochondrial dysfunction, PKCδ activation, and neuronal loss. The PKCδ inhibition and neuroprotection mediated by GRe were comparable to those by the ROS inhibitor N-acetylcysteine, the mitochondrial protectant cyclosporin A, the microglial inhibitor minocycline, or the PKCδ inhibitor rottlerin. Consistently, the GRe-mediated PKCδ inhibition and neuroprotection were counteracted by the mitochondrial toxin 3-nitropropionic acid or the PKC activator bryostatin-1. GRe treatment did not have additional effects on PKCδ gene knockout-mediated neuroprotection, suggesting that PKCδ is a molecular target of GRe. Collectively, our results suggest that GRe-mediated anticonvulsive/neuroprotective effects require the attenuation of mitochondrial dysfunction and altered redox status and inactivation of PKCδ. © 2023 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Ginsenoside Re blocks Bay k-8644-induced neurotoxicity via attenuating mitochondrial dysfunction and PKCδ activation in the hippocampus of mice: Involvement of antioxidant potential | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.fct.2023.113869 | - |
dc.identifier.bibliographicCitation | Food and Chemical Toxicology, v.178 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001024483500001 | - |
dc.identifier.scopusid | 2-s2.0-85163773821 | - |
dc.citation.title | Food and Chemical Toxicology | - |
dc.citation.volume | 178 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Convulsive neurotoxicity | - |
dc.subject.keywordAuthor | Ginsenoside Re | - |
dc.subject.keywordAuthor | L-type calcium channel activator Bay k-8644 | - |
dc.subject.keywordAuthor | Mitochondrial dysfunction with altered redox status | - |
dc.subject.keywordAuthor | Mouse hippocampus | - |
dc.subject.keywordAuthor | Protein kinase Cδ gene | - |
dc.subject.keywordPlus | KINASE-C-DELTA | - |
dc.subject.keywordPlus | TRIMETHYLTIN-INDUCED NEUROTOXICITY | - |
dc.subject.keywordPlus | PROTEIN-KINASE | - |
dc.subject.keywordPlus | CALCIUM-CHANNEL | - |
dc.subject.keywordPlus | 3-NITROPROPIONIC ACID | - |
dc.subject.keywordPlus | KAINIC ACID | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MOLECULAR-MECHANISMS | - |
dc.subject.keywordPlus | SEIZURES | - |
dc.subject.keywordPlus | MINOCYCLINE | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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