Etiology of Prostatic Reactivation of Embryonic Growth Pathways 1: Chronic Inflammation

Abstract

Traditionally, androgens and ageing have been considered confirmative main factors of prostate enlargement. McNeal noted that the proliferation closely resembled developmental differentiation and posited that epithelial hyperplasia may be the result of reactivation of embryonic pathways. He postulated that the combined stromal and ductal hyperplasia in aging men resulted from a re-awakening of these mesenchymal-epithelial inductive interactions. Latest years, acute and chronic inflammation of the prostate and decreasing testosterone levels may important in the aging related re-awakening. So aim of this article is to provide a review of the role of chronic inflammation in benign prostate hyperplasia.