Histopathological Evaluation of Non-Neoplastic Renal Parenchyma Adjacent to Tumors in Partial Nephrectomy Specimens of Renal Cell Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Sang Hyup Lee | - |
dc.contributor.author | Tae-Hyoung Kim | - |
dc.contributor.author | Soon Chul Myung | - |
dc.contributor.author | Young Tae Moon | - |
dc.contributor.author | Kyung Do Kim | - |
dc.contributor.author | Jung Hoon Kim | - |
dc.date.accessioned | 2024-01-18T08:30:25Z | - |
dc.date.available | 2024-01-18T08:30:25Z | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 2951-603X | - |
dc.identifier.issn | 2982-7043 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71088 | - |
dc.description.abstract | Purpose: The optimal margin for partial nephrectomy of renal cell carcinoma (RCC) has not been clearly defined. We investigated the viability of glomeruli and tubules in non-neoplastic renal parenchyma adjacent to tumors and analyzed the predictive factors that affect them.Materials and Methods: Data were gathered retrospectively from 64 patients who underwent partial nephrectomy for RCC between January 2008 and December 2011. We evaluated glomerular viability of non-neoplastic renal parenchyma adjacent to tumors using H&E staining and tubular viability was assessed by Klotho stain. Each renal unit was assigned a RENAL nephrometry score using preoperative imaging. We also investigated the correlation between RENAL score, estimated glomerular filtration rate (GFR) and glomerular and tubular viability.Results: The percentage of non-viable glomeruli was higher in the region within 2-mm from the tumor compared with the region>2-mm from the tumor. The mean non-viable tubular distance from the tumor was 1.36±0.597mm. Only the correlation between glomerular non-viability (%) within 2-mm from the tumor and non-viable tubular distance (mm) was significant. Correlations between RENAL score and glomerular non-viability in the region ≤2- mm from the tumor and non-viable tubular distance were not significant for all RENAL factors. But, glomerular non-viability 5-10-mm from the tumor was inversely correlated with preoperative estimated GFR.Conclusions: Regardless of RENAL nephrometry scores, the viability of glomeruli and tubules within 2-mm from RCC was affected by tumor mass, and that >5-mm from the tumor was affected by subclinical comorbidities. These may suggest new guidelines of RCC management intraoperatively and postoperatively. | - |
dc.format.extent | 8 | - |
dc.publisher | 대한비뇨기종양학회 | - |
dc.title | Histopathological Evaluation of Non-Neoplastic Renal Parenchyma Adjacent to Tumors in Partial Nephrectomy Specimens of Renal Cell Carcinoma | - |
dc.type | Article | - |
dc.identifier.bibliographicCitation | Journal of Urologic Oncology, v.11, no.1, pp 33 - 40 | - |
dc.description.isOpenAccess | N | - |
dc.citation.endPage | 40 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.title | Journal of Urologic Oncology | - |
dc.citation.volume | 11 | - |
dc.identifier.url | https://www.e-juo.org/journal/view.php?number=277 | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Renal cell carcinoma | - |
dc.subject.keywordAuthor | Renal parenchyma | - |
dc.subject.keywordAuthor | Nephrectomy | - |
dc.description.journalRegisteredClass | domestic | - |
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