Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size
DC Field | Value | Language |
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dc.contributor.author | Hackeng, Wenzel M | - |
dc.contributor.author | Brosens, Lodewijk A A | - |
dc.contributor.author | Kim, Joo Young | - |
dc.contributor.author | O'Sullivan, Roderick | - |
dc.contributor.author | Sung, You-Na | - |
dc.contributor.author | Liu, Ta-Chiang | - |
dc.contributor.author | Cao, Dengfeng | - |
dc.contributor.author | Heayn, Michelle | - |
dc.contributor.author | Brosnan-Cashman, Jacqueline | - |
dc.contributor.author | An, Soyeon | - |
dc.contributor.author | Morsink, Folkert H M | - |
dc.contributor.author | Heidsma, Charlotte M | - |
dc.contributor.author | Valk, Gerlof D | - |
dc.contributor.author | Vriens, Menno R | - |
dc.contributor.author | Nieveen, Van Dijkum Els | - |
dc.contributor.author | Offerhaus, G Johan A | - |
dc.contributor.author | Dreijerink, Koen M A | - |
dc.contributor.author | Zeh, Herbert | - |
dc.contributor.author | Zureikat, Amer H | - |
dc.contributor.author | Hogg, Melissa | - |
dc.contributor.author | Lee, Kenneth | - |
dc.contributor.author | Geller, David | - |
dc.contributor.author | Marsh, J Wallis | - |
dc.contributor.author | Paniccia, Alessandro | - |
dc.contributor.author | Ongchin, Melanie | - |
dc.contributor.author | Pingpank, James F | - |
dc.contributor.author | Bahary, Nathan | - |
dc.contributor.author | Aijazi, Muaz | - |
dc.contributor.author | Brand, Randall | - |
dc.contributor.author | Chennat, Jennifer | - |
dc.contributor.author | Das, Rohit | - |
dc.contributor.author | Fasanella, Kenneth E | - |
dc.contributor.author | Khalid, Asif | - |
dc.contributor.author | McGrath, Kevin | - |
dc.contributor.author | Sarkaria, Savreet | - |
dc.contributor.author | Singh, Harkirat | - |
dc.contributor.author | Slivka, Adam | - |
dc.contributor.author | Nalesnik, M.ichael | - |
dc.contributor.author | Han, Xiaoli | - |
dc.contributor.author | Nikiforova, Marina N | - |
dc.contributor.author | Lawlor, Rita Teresa | - |
dc.contributor.author | Mafficini, Andrea | - |
dc.contributor.author | Rusev, Boris | - |
dc.contributor.author | Corbo, Vincenzo | - |
dc.contributor.author | Luchini, Claudio | - |
dc.contributor.author | Bersani, Samantha | - |
dc.contributor.author | Pea, Antonio | - |
dc.contributor.author | Cingarlini, Sara | - |
dc.contributor.author | Landoni, Luca | - |
dc.contributor.author | Salvia, Roberto | - |
dc.contributor.author | Milione, Massimo | - |
dc.contributor.author | Milella, Michele | - |
dc.contributor.author | Scarpa, Aldo | - |
dc.contributor.author | Hong, Seung-Mo | - |
dc.contributor.author | Heaphy, Christopher M | - |
dc.contributor.author | Singhi, Aatur D | - |
dc.date.accessioned | 2024-01-19T05:01:58Z | - |
dc.date.available | 2024-01-19T05:01:58Z | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0017-5749 | - |
dc.identifier.issn | 1468-3288 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71176 | - |
dc.description.abstract | Objective Recent studies have found aristaless-related homeobox gene (ARX)/pancreatic and duodenal homeobox 1 (PDX1), alpha-thalassemia/mental retardation X-linked (ATRX)/death domain-associated protein (DAXX) and alternative lengthening of telomeres (ALT) to be promising prognostic biomarkers for non-functional pancreatic neuroendocrine tumours (NF-PanNETs). However, they have not been comprehensively evaluated, especially among small NF-PanNETs (≤2.0 cm). Moreover, their status in neuroendocrine tumours (NETs) from other sites remains unknown. Design An international cohort of 1322 NETs was evaluated by immunolabelling for ARX/PDX1 and ATRX/DAXX, and telomere-specific fluorescence in situ hybridisation for ALT. This cohort included 561 primary NF-PanNETs, 107 NF-PanNET metastases and 654 primary, non-pancreatic non-functional NETs and NET metastases. The results were correlated with numerous clinicopathological features including relapse-free survival (RFS). Results ATRX/DAXX loss and ALT were associated with several adverse prognostic findings and distant metastasis/recurrence (p<0.001). The 5-year RFS rates for patients with ATRX/DAXX-negative and ALT-positive NF-PanNETs were 40% and 42% as compared with 85% and 86% for wild-type NF-PanNETs (p<0.001 and p<0.001). Shorter 5-year RFS rates for ≤2.0 cm NF-PanNETs patients were also seen with ATRX/DAXX loss (65% vs 92%, p=0.003) and ALT (60% vs 93%, p<0.001). By multivariate analysis, ATRX/DAXX and ALT status were independent prognostic factors for RFS. Conversely, classifying NF-PanNETs by ARX/PDX1 expression did not independently correlate with RFS. Except for 4% of pulmonary carcinoids, ATRX/DAXX loss and ALT were only identified in primary (25% and 29%) and NF-PanNET metastases (62% and 71%). Conclusions ATRX/DAXX and ALT should be considered in the prognostic evaluation of NF-PanNETs including ≤2.0 cm tumours, and are highly specific for pancreatic origin among NET metastases of unknown primary. © | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMJ Publishing Group | - |
dc.title | Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size | - |
dc.type | Article | - |
dc.identifier.doi | 10.1136/gutjnl-2020-322595 | - |
dc.identifier.bibliographicCitation | Gut, v.71, no.5, pp 961 - 973 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85104459455 | - |
dc.citation.endPage | 973 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 961 | - |
dc.citation.title | Gut | - |
dc.citation.volume | 71 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | neuroendocrine tumors | - |
dc.subject.keywordAuthor | pancreatic endocrine tumour | - |
dc.subject.keywordAuthor | pancreatic islet cell | - |
dc.subject.keywordAuthor | pancreatic pathology | - |
dc.subject.keywordAuthor | pancreatic surgery | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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