Low HES-1 and positive DLL4 expression predicts poor prognosis of colorectal cancers
DC Field | Value | Language |
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dc.contributor.author | Kim, Gilhyang | - |
dc.contributor.author | Jung, Jiyoon | - |
dc.contributor.author | Kim, Jeong Won | - |
dc.contributor.author | Kim, Joo Young | - |
dc.date.accessioned | 2024-01-19T05:30:20Z | - |
dc.date.available | 2024-01-19T05:30:20Z | - |
dc.date.issued | 2023-02 | - |
dc.identifier.issn | 0031-3025 | - |
dc.identifier.issn | 1465-3931 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71178 | - |
dc.description.abstract | Hairy and enhancer of split-1 (HES-1) is a downstream transcription factor and delta-like 4 (DLL4) is a ligand of the Notch signalling pathway. HES-1 and DLL4 expression are known to have an association with the progression and metastasis of cancers. We evaluated HES-1 and DLL4 expression and assessed their correlation with biological behaviour and prognostic significance of 327 colorectal cancers. Low HES-1 expression was identified in 210 (64.2%) cases and was significantly correlated with large tumour size, lymphovascular invasion, and distant metas-tasis. DLL4 was positive in 132 (40.4%) cases and significantly correlated with perineural invasion, distant metastasis, and involved resection margin. Patients with low HES-1 expression showed significantly worse overall survival than patients with high HES-1 expression [hazard ratio (HR)=3.017; 95% confidence interval (CI) 1.880-4.841; p<0.001]. The overall survival of patients with positive DLL4 expression was significantly worse than that of patients with negative DLL4 expression (HR=2.922; 95% CI 1.976-4.322; p<0.001). Furthermore, the com-bined HES-1lowDLL4positive expression group showed the worst overall survival compared to other groups (p<0.001) and was an independent poor prognostic factor of colo-rectal cancer patients. Thus, low HES-1 and positive DLL4 expression are associated with aggressive biological behaviour and can be used as prognostic factors in colo-rectal cancer patients. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER | - |
dc.title | Low HES-1 and positive DLL4 expression predicts poor prognosis of colorectal cancers | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.pathol.2022.07.008 | - |
dc.identifier.bibliographicCitation | PATHOLOGY, v.55, no.1, pp 52 - 57 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000920798800001 | - |
dc.identifier.scopusid | 2-s2.0-85139255940 | - |
dc.citation.endPage | 57 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 52 | - |
dc.citation.title | PATHOLOGY | - |
dc.citation.volume | 55 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Colorectal cancers | - |
dc.subject.keywordAuthor | HES-1 | - |
dc.subject.keywordAuthor | DLL4 | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordPlus | TUMOR-GROWTH | - |
dc.subject.keywordPlus | NOTCH | - |
dc.subject.keywordPlus | METASTASIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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