약물에 의한 중증 피부반응

Abstract

Severe adverse cutaneous reactions (SCARs) include Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) anddrug reaction with eosinophilia and systemic symptoms (DRESS). Although recent advances in pharmacogenomics have revealedthe association between specific human leukocyte antigens (HLAs) and certain drug-induced SCARs, such associations were foundin a limited number of drug-associated SCARs and are not sufficient to explain many other drug-related SCARs. After introducingresearch on the HLA-restricted T cell response, the role of the T cell receptor in drug binding was emphasized and a new conceptcalled “pharmacological interactions of drug with immune receptors” has been conceptualized over recent decades. Currently,many international and domestic collaborative consortia have been formed and should enable the phenotypic standardization ofSCARs at the earliest practicable time to provide valuable insights into its pathogenesis and to find an ideal method to prevent patientsfrom developing SCARs.