Engineering of Cell Derived-Nanovesicle as an Alternative to Exosome Therapy
DC Field | Value | Language |
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dc.contributor.author | Jang, Hye-Jeong | - |
dc.contributor.author | Shim, Kyu-Sik | - |
dc.contributor.author | Lee, Jinah | - |
dc.contributor.author | Park, Joo Hyeon | - |
dc.contributor.author | Kang, Seong-Jun | - |
dc.contributor.author | Shin, Young Min | - |
dc.contributor.author | Lee, Jung Bok | - |
dc.contributor.author | Baek, Wooyeol | - |
dc.contributor.author | Yoon, Jeong-Kee | - |
dc.date.accessioned | 2024-01-23T02:30:44Z | - |
dc.date.available | 2024-01-23T02:30:44Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 1738-2696 | - |
dc.identifier.issn | 2212-5469 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71278 | - |
dc.description.abstract | BackgroundExosomes, nano-sized vesicles ranging between 30 and 150 nm secreted by human cells, play a pivotal role in long-range intercellular communication and have attracted significant attention in the field of regenerative medicine. Nevertheless, their limited productivity and cost-effectiveness pose challenges for clinical applications. These issues have recently been addressed by cell-derived nanovesicles (CDNs), which are physically synthesized exosome-mimetic nanovesicles from parent cells, as a promising alternative to exosomes. CDNs exhibit structural, physical, and biological properties similar to exosomes, containing intracellular protein and genetic components encapsulated by the cell plasma membrane. These characteristics allow CDNs to be used as regenerative medicine and therapeutics on their own, or as a drug delivery system.MethodsThe paper reviews diverse methods for CDN synthesis, current analysis techniques, and presents engineering strategies to improve lesion targeting efficiency and/or therapeutic efficacy.ResultsCDNs, with their properties similar to those of exosomes, offer a cost-effective and highly productive alternative due to their non-living biomaterial nature, nano-size, and readiness for use, allowing them to overcome several limitations of conventional cell therapy methods.ConclusionOngoing research and enhancement of CDNs engineering, along with comprehensive safety assessments and stability analysis, exhibit vast potential to advance regenerative medicine by enabling the development of efficient therapeutic interventions. | - |
dc.format.extent | 19 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN TISSUE ENGINEERING REGENERATIVE MEDICINE SOC | - |
dc.title | Engineering of Cell Derived-Nanovesicle as an Alternative to Exosome Therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s13770-023-00610-4 | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING AND REGENERATIVE MEDICINE, v.21, no.1, pp 1 - 19 | - |
dc.identifier.kciid | ART003039446 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001116617700001 | - |
dc.identifier.scopusid | 2-s2.0-85178924160 | - |
dc.citation.endPage | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.title | TISSUE ENGINEERING AND REGENERATIVE MEDICINE | - |
dc.citation.volume | 21 | - |
dc.type.docType | Review | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Cell-derived nanovesicles | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | Exosomes | - |
dc.subject.keywordAuthor | Regenerative medicine | - |
dc.subject.keywordPlus | MESENCHYMAL STEM-CELLS | - |
dc.subject.keywordPlus | EXTRACELLULAR VESICLES | - |
dc.subject.keywordPlus | MIMETIC NANOVESICLES | - |
dc.subject.keywordPlus | MEMBRANE-VESICLES | - |
dc.subject.keywordPlus | ENDOGENOUS RNA | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | MICROVESICLES | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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