Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Characterization of acute-on-chronic liver failure and prediction of mortality in Asian patients with active alcoholism

Full metadata record
DC Field Value Language
dc.contributor.authorKim, Hwi Young-
dc.contributor.authorChang, Young-
dc.contributor.authorPark, Jae Yong-
dc.contributor.authorAhn, Hongkeun-
dc.contributor.authorCho, Hyeki-
dc.contributor.authorHan, Seung Jun-
dc.contributor.authorOh, Sohee-
dc.contributor.authorKim, Donghee-
dc.contributor.authorJung, Yong Jin-
dc.contributor.authorKim, Byeong Gwan-
dc.contributor.authorLee, Kook Lae-
dc.contributor.authorKim, Won-
dc.date.accessioned2024-01-31T04:30:48Z-
dc.date.available2024-01-31T04:30:48Z-
dc.date.issued2016-02-
dc.identifier.issn0815-9319-
dc.identifier.issn1440-1746-
dc.identifier.urihttps://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71627-
dc.description.abstractBackground and AimsAlcoholic liver diseases often evolve to acute-on-chronic liver failure (ACLF), which increases the risk of (multi-)organ failure and death. We investigated the development and characteristics of alcohol-related ACLF and evaluated prognostic scores for prediction of mortality in Asian patients with active alcoholism. MethodsA total of 205 patients who were hospitalized with severe alcoholic liver disease were included in this retrospective cohort study, after excluding those with serious cardiovascular diseases, malignancy, or co-existing viral hepatitis. The Chronic Liver Failure (CLIF) Consortium Organ Failure score was used in the diagnosis and grading of ACLF, and the CLIF Consortium ACLF score (CLIF-C ACLFs) was used to predict mortality. ResultsPatients with ACLF had higher Maddrey discriminant function, model for end-stage liver disease (MELD), and MELD-sodium scores than those without ACLF. Infections were more frequently documented in patients with ACLF (33.3% vs 53.0%; P=0.004). Predictive factors for ACLF development were systemic inflammatory response syndrome (odds ratio [OR], 2.239; P<0.001), serum sodium level (OR, 0.939; P=0.029), and neutrophil count (OR, 1.000; P=0.021). For prediction of mortality at predefined time points (28-day and 90-day) in patients with ACLF, areas under the receiver-operating characteristic were significantly greater for the CLIF-C ACLFs than for Child-Pugh, MELD, and MELD-sodium scores. ConclusionsInfection and systemic inflammatory response syndrome play an important role in the development of alcohol-related ACLF in Asian patients with active alcoholism. The CLIF-C ACLFs may be more useful for predicting mortality in ACLF cases than liver-specific scoring systems.-
dc.format.extent7-
dc.language영어-
dc.language.isoENG-
dc.publisherWILEY-
dc.titleCharacterization of acute-on-chronic liver failure and prediction of mortality in Asian patients with active alcoholism-
dc.typeArticle-
dc.identifier.doi10.1111/jgh.13084-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.31, no.2, pp 427 - 433-
dc.description.isOpenAccessN-
dc.identifier.wosid000369398400023-
dc.identifier.scopusid2-s2.0-84955593009-
dc.citation.endPage433-
dc.citation.number2-
dc.citation.startPage427-
dc.citation.titleJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.citation.volume31-
dc.type.docTypeArticle-
dc.publisher.location미국-
dc.subject.keywordAuthoracute-on-chronic liver failure-
dc.subject.keywordAuthoralcoholic liver disease-
dc.subject.keywordAuthormortality-
dc.subject.keywordAuthorprediction-
dc.subject.keywordPlusSERUM SODIUM-
dc.subject.keywordPlusCIRRHOSIS-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordPlusPROGNOSIS-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Files in This Item
There are no files associated with this item.
Appears in
Collections
ETC > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Park, Jae Yong photo

Park, Jae Yong
의과대학 (의학부(임상-서울))
Read more

Altmetrics

Total Views & Downloads

BROWSE