Abnormal histone replacement following BPA exposure affects spermatogenesis and fertility sequentially
DC Field | Value | Language |
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dc.contributor.author | Ryu, D.-Y. | - |
dc.contributor.author | Pang, W.-K. | - |
dc.contributor.author | Adegoke, E.O. | - |
dc.contributor.author | Rahman, M.S. | - |
dc.contributor.author | Park, Y.-J. | - |
dc.contributor.author | Pang, M.-G. | - |
dc.date.accessioned | 2024-02-02T06:00:27Z | - |
dc.date.available | 2024-02-02T06:00:27Z | - |
dc.date.issued | 2022-12 | - |
dc.identifier.issn | 0160-4120 | - |
dc.identifier.issn | 1873-6750 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71693 | - |
dc.description.abstract | Bisphenol A (BPA) is an endocrine-disrupting chemical widely distributed in the environment. Its exposure has been linked to male infertility in animals and humans due to its ability to induce epigenetic modification. Despite extensive research confirming the impact of BPA on epigenetic regulation, fundamental concerns about how BPA causes epigenetic changes and the underlying mechanism of BPA on the male reproductive system remain unresolved. Therefore, we sought to investigate the effects of BPA on epigenetic regulation and the histone-to-protamine (PRM) transition, which is fundamental process for male fertility in testes and spermatozoa by exposing male mice to BPA for 6 weeks while giving the mice in the control group corn oil by oral gavage. Our results demonstrated that the mRNA levels of the histone family and PRMs were significantly altered by BPA exposure in testes and spermatozoa. Subsequently, core histone proteins, the PRM1/PRM2 ratio, directly linked to male fertility, and transition proteins were significantly reduced. Furthermore, we discovered that BPA significantly caused abnormal histone-to-protamine replacement during spermiogenesis by increased histone variants-related to histone-to-PRM transition. The levels of histone H3 modification in the testes and DNA methylation in spermatozoa were significantly increased. Consequently, sperm concentration/motility/hyperactivation, fertilization, and early embryonic development were adversely affected as a consequence of altered signaling proteins following BPA exposure. To our knowledge, this is the first study to indicate that BPA exposure influences the histone-to-PRM transition via altering epigenetic modification and eventually causing reduced male fertility. © 2022 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Abnormal histone replacement following BPA exposure affects spermatogenesis and fertility sequentially | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.envint.2022.107617 | - |
dc.identifier.bibliographicCitation | Environment International, v.170 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000913180200004 | - |
dc.identifier.scopusid | 2-s2.0-85141295884 | - |
dc.citation.title | Environment International | - |
dc.citation.volume | 170 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Bisphenol A | - |
dc.subject.keywordAuthor | Epigenetic modification | - |
dc.subject.keywordAuthor | Histone-to-protamine transition | - |
dc.subject.keywordAuthor | Male fertility | - |
dc.subject.keywordPlus | ENDOCRINE DISRUPTING CHEMICALS | - |
dc.subject.keywordPlus | SPERM DNA FRAGMENTATION | - |
dc.subject.keywordPlus | TO-PROTAMINE TRANSITION | - |
dc.subject.keywordPlus | BISPHENOL-A | - |
dc.subject.keywordPlus | HUMAN HEALTH | - |
dc.subject.keywordPlus | VARIANT | - |
dc.subject.keywordPlus | SPERMATOZOA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | METHYLATION | - |
dc.subject.keywordPlus | INFERTILITY | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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