Seroconversion of red blood cell antibody in ABO-incompatible living donor liver transplantation -a case reportopen access
- Authors
- Lee, Eun Kyung; Song, Insun; Kim, Gaab Soo
- Issue Date
- Jun-2020
- Publisher
- KOREAN SOC ANESTHESIOLOGISTS
- Keywords
- Erythrocytes; Liver transplantation; Plasmapheresis; Red blood cell antibody screen test; Rituximab
- Citation
- KOREAN JOURNAL OF ANESTHESIOLOGY, v.73, no.3, pp 252 - 256
- Pages
- 5
- Journal Title
- KOREAN JOURNAL OF ANESTHESIOLOGY
- Volume
- 73
- Number
- 3
- Start Page
- 252
- End Page
- 256
- URI
- https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71743
- DOI
- 10.4097/kja.19141
- ISSN
- 2005-6419
2005-7563
- Abstract
- Background: Liver transplantation usually requires blood transfusion, and a red blood cell (RBC) antibody screen is essential for the prevention of a hemolytic reaction. Since proper ABO-compatible grafts are lacking, ABO-incompatible living donor liver transplantation (ABO-i LDLT) with desensitization is a feasible therapy. Desensitization includes intravenous rituximab injection and plasmapheresis before surgery. Case: A 60-year-old female was diagnosed with hepatitis B virus-related hepatocellular carcinoma and planned for ABO-i LDLT. She tested positive in a RBC antibody screen over two years; however, she tested negative for the test after desensitization. Clinicians noted the seroconversion during induction, and thus, a delay in the preparation of adequate packed RBC was unavoidable. Conclusions: Even when the latest RBC antibody screen is negative after immunosuppression, clinicians should consider the possibility of a prior positive result to promote safer medical treatment and management.
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