The Updated World Health Organization Classification Better Predicts Survival in Patients With Endocervical Adenocarcinoma (KROG 20-07)
DC Field | Value | Language |
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dc.contributor.author | Cho, W.K. | - |
dc.contributor.author | Kim, H.-S. | - |
dc.contributor.author | Park, W. | - |
dc.contributor.author | Kim, Y.-S. | - |
dc.contributor.author | Kang, J. | - |
dc.contributor.author | Kim, Y.B. | - |
dc.contributor.author | Kim, Y.S. | - |
dc.contributor.author | Kim, Y.J. | - |
dc.contributor.author | Kim, K.-R. | - |
dc.contributor.author | Kim, J.H. | - |
dc.contributor.author | Kwon, S.Y. | - |
dc.contributor.author | Choi, J.H. | - |
dc.contributor.author | Yoon, M. | - |
dc.contributor.author | Kim, N.I. | - |
dc.date.accessioned | 2024-02-05T06:30:23Z | - |
dc.date.available | 2024-02-05T06:30:23Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 0360-3016 | - |
dc.identifier.issn | 1879-355X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71774 | - |
dc.description.abstract | Purpose: The 2020 World Health Organization classification divided endocervical adenocarcinoma (ADC) into human papillomavirus–associated (HPVA) and human papillomavirus–independent (HPVI) ADCs. This multi-institutional study aimed to investigate the clinical features and prognosis of patients with endocervical ADC based on the updated World Health Organization classification. Methods and Materials: We retrospectively reviewed the 365 patients with endocervical ADC who underwent radical hysterectomy from 7 institutions. Tumor characteristics, patterns of failure, and survival outcomes were compared between HPVA and HPVI ADCs. Results: Two hundred seventy-five (75.3%) and 90 (24.7%) patients had HPVA and HPVI ADC diagnoses, respectively. In all cases, the 5-year disease-free survival (DFS) and overall survival (OS) rates were 58.2% and 71.3%, respectively. HPVI ADC showed higher rates of local recurrence (25.6% vs 10.9%) and distant metastasis (33.3% vs 17.5%) than HPVA ADC. Multivariate survival analysis revealed that HPVI ADC showed significantly worse DFS (hazard ratio [HR], 1.919; 95% confidence interval [CI], 1.324-2.781; P < .001), distant metastasis-free survival (HR, 2.100; 95% CI, 1.397-3.156; P < .001), and OS (HR, 2.481; 95% CI, 1.586-3.881; P < .001) than HPVA ADC. Patients with gastric- and serous-type HPVI ADC had significantly worse OS than those with other HPVI ADCs (P = .020). Similarly, invasive stratified mucin-producing–type HPVA ADC showed significantly worse OS than other HPVA ADCs (P < .001). Conclusions: We demonstrated that HPVI ADC exhibited inferior DFS and OS and higher rates of local and distant recurrence compared with HPVA ADC. Gastric- and serous-type HPVI ADCs and invasive stratified mucin-producing–type HPVA ADC showed worse OS than other types of HPVI and HPVA ADCs, respectively. Our observation of significant differences in prognoses according to the histologic types needs to be validated in larger cohorts of patients with endocervical ADC. © 2023 Elsevier Inc. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Inc. | - |
dc.title | The Updated World Health Organization Classification Better Predicts Survival in Patients With Endocervical Adenocarcinoma (KROG 20-07) | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijrobp.2023.03.048 | - |
dc.identifier.bibliographicCitation | International Journal of Radiation Oncology Biology Physics, v.117, no.1, pp 154 - 163 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001069465900001 | - |
dc.identifier.scopusid | 2-s2.0-85152291949 | - |
dc.citation.endPage | 163 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 154 | - |
dc.citation.title | International Journal of Radiation Oncology Biology Physics | - |
dc.citation.volume | 117 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | RECURRENT KRAS MUTATIONS | - |
dc.subject.keywordPlus | SQUAMOUS-CELL CARCINOMA | - |
dc.subject.keywordPlus | MUCINOUS CARCINOMA | - |
dc.subject.keywordPlus | TREATMENT OUTCOMES | - |
dc.subject.keywordPlus | UTERINE CERVIX | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | RADIOTHERAPY | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | GAIN | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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