Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogel
DC Field | Value | Language |
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dc.contributor.author | Khunmanee, Sureerat | - |
dc.contributor.author | Choi, Anseo | - |
dc.contributor.author | Ahn, Il Young | - |
dc.contributor.author | Kim, Woo Ju | - |
dc.contributor.author | Bae, Tae Hui | - |
dc.contributor.author | Kang, Shin Hyuk | - |
dc.contributor.author | Park, Hansoo | - |
dc.date.accessioned | 2024-02-07T05:30:36Z | - |
dc.date.available | 2024-02-07T05:30:36Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 2589-0042 | - |
dc.identifier.issn | 2589-0042 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71829 | - |
dc.description.abstract | Current trends in wound care research focus on creating dressings for diverse wound types, aiming to effectively control the wound healing process. We proposed a wound dressing composed of oxidized hyaluronic acid and amine gelatin with embedded lysine-modified gelatin nanoparticles (HGel-GNPs-lysine). This dressing improves mechanical properties and reduces degradation rates. The storage modulus for HGel-GNPs-lysine was 3,800 Pa, exceeding that of HGel (1,750 Pa). The positively charged surface of GNPs-lysine effectively eliminated Escherichia coli and Staphylococcus aureus. In a diabetic mice model (C57BL/6), HGel-GNPs-lysine immobilized with basic-fibroblast growth factor promoted granulation tissue thickness and collagen density. Gene expression analysis indicated that HGel-GNPs-lysine reduced inflammation and enhanced angiogenesis. This study highlights that HGel-GNPs-lysine could offer alternative treatment strategies for regulating the inflammatory response at the injury site in wound dressing applications. © 2024 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Inc. | - |
dc.title | Effective wound healing on diabetic mice by adhesive antibacterial GNPs-lysine composited hydrogel | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.isci.2024.108860 | - |
dc.identifier.bibliographicCitation | iScience, v.27, no.2 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 001170450100001 | - |
dc.identifier.scopusid | 2-s2.0-85183118013 | - |
dc.citation.number | 2 | - |
dc.citation.title | iScience | - |
dc.citation.volume | 27 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Bioengineering | - |
dc.subject.keywordAuthor | Biomaterials | - |
dc.subject.keywordAuthor | Biotechnology | - |
dc.subject.keywordAuthor | Materials science | - |
dc.subject.keywordPlus | NANOCOMPOSITE HYDROGELS | - |
dc.subject.keywordPlus | HYALURONIC-ACID | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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