Persistent Antibody Responses Up to 18 Months After Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection
DC Field | Value | Language |
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dc.contributor.author | Choe, Pyoeng Gyun | - |
dc.contributor.author | Hong, Jisu | - |
dc.contributor.author | Park, Jiyoung | - |
dc.contributor.author | Chang, Euijin | - |
dc.contributor.author | Kang, Chang Kyung | - |
dc.contributor.author | Kim, Nam Joong | - |
dc.contributor.author | Lee, Chang-Han | - |
dc.contributor.author | Park, Wan Beom | - |
dc.contributor.author | Oh, Myoung-don | - |
dc.date.accessioned | 2024-02-08T05:30:28Z | - |
dc.date.available | 2024-02-08T05:30:28Z | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.issn | 1537-6613 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/71867 | - |
dc.description.abstract | Despite decreasing over time, humoral immunity persisted for up to 18 months after SARS-CoV-2 infection in persons who had recovered from mild COVID-19. However, humoral immune activity against more recently circulating viral variants was reduced in this population. Background Humoral immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may wane rapidly in persons recovered from mild coronavirus disease 2019 (COVID-19), but little is known about the longevity. Methods Serum samples were obtained 8, 12, and 18 months after infection from 20 patients with mild COVID-19. The binding activities of serum antibodies (immunoglobulin [Ig]A, IgG, and IgM) against SARS-CoV-2 antigens of the Wuhan-1 reference strain (wild-type) and the B.1.1.7, P.1, B.1.167.2, and B.1.1.529 variants were measured by enzyme-linked immunosorbent assays. Neutralizing antibody titers were measured using a cytopathic effect-based live virus neutralization assay. Results Serum IgA and IgG antibodies against spike or receptor-binding domain (RBD) protein of wild-type SARS-CoV-2 were detected for up to 18 months, and neutralizing antibodies persisted for 8 to 18 months after infection. However, any significant antibody responses against RBD proteins of SARS-CoV-2 variants were not observed, and median neutralizing antibody titers against the Delta variant at 8, 12, and 18 months were 8- to 11-fold lower than against wild-type viruses (P<.001). Conclusions Humoral immunity persisted for up to 18 months after SARS-CoV-2 infection in patients with mild COVID-19. However, humoral immune activity against more recently circulating variants was reduced in this population. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | Persistent Antibody Responses Up to 18 Months After Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/infdis/jiac099 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTIOUS DISEASES, v.226, no.7, pp 1224 - 1230 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000784665200001 | - |
dc.identifier.scopusid | 2-s2.0-85139375978 | - |
dc.citation.endPage | 1230 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1224 | - |
dc.citation.title | JOURNAL OF INFECTIOUS DISEASES | - |
dc.citation.volume | 226 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | ELISA | - |
dc.subject.keywordAuthor | neutralizing antibodies | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | serological response | - |
dc.subject.keywordPlus | SARS-COV-2 | - |
dc.subject.keywordPlus | REINFECTION | - |
dc.subject.keywordPlus | RISK | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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