Staphylococcal enterotoxin IgE sensitization in late-onset severe eosinophilic asthma in the elderly
DC Field | Value | Language |
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dc.contributor.author | Song, W-J. | - |
dc.contributor.author | Sintobin, I. | - |
dc.contributor.author | Sohn, K-H. | - |
dc.contributor.author | Kang, M-G. | - |
dc.contributor.author | Park, H-K. | - |
dc.contributor.author | Jo, E-J. | - |
dc.contributor.author | Lee, S-E. | - |
dc.contributor.author | Yang, M-S. | - |
dc.contributor.author | Kim, S-H. | - |
dc.contributor.author | Park, H-K. | - |
dc.contributor.author | Kwon, Y. E. | - |
dc.contributor.author | Kim, T-B. | - |
dc.contributor.author | Kim, S-H. | - |
dc.contributor.author | Park, H-W. | - |
dc.contributor.author | Chang, Y-S. | - |
dc.contributor.author | Lee, B-J. | - |
dc.contributor.author | Jee, Y-K. | - |
dc.contributor.author | Choi, B. W. | - |
dc.contributor.author | Bachert, C. | - |
dc.contributor.author | Cho, S-H. | - |
dc.date.available | 2019-03-08T13:38:05Z | - |
dc.date.issued | 2016-03 | - |
dc.identifier.issn | 0954-7894 | - |
dc.identifier.issn | 1365-2222 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/7205 | - |
dc.description.abstract | BackgroundAsthma in the elderly (aged 65years old) is a significant concern with high morbidity, but the pathophysiology remains unclear particularly in late-onset asthma. Recent studies suggest staphylococcal enterotoxin IgE (SE-IgE) sensitization to be a risk factor for asthma in general populations; however, the associations have not been examined in late-onset elderly asthma. ObjectiveWe aimed to examine the associations of SE-IgE sensitization with late-onset asthma in the elderly, using a database of elderly asthma cohort study. MethodsA total of 249 elderly patients with asthma and 98 controls were analysed. At baseline, patients were assessed for demographics, atopy, induced sputum profiles and comorbidities including chronic rhinosinusitis (CRS). Serum total IgE and SE-IgE levels were measured. Asthma severity was assessed on the basis of asthma outcomes during a 12-month follow-up period. ResultsAt baseline, serum SE-IgE concentrations were significantly higher in patients with asthma than in controls [median 0.16 (interquartile range 0.04-0.53) vs. 0.10 (0.01-0.19), P<0.001]. Elderly asthma patients with high SE-IgE levels had specific characteristics of having more severe asthma, sputum eosinophilia and CRS, compared to those with lower SE-IgE levels. In multivariate logistic regression analyses, the associations between serum SE-IgE concentrations and severe asthma were significant, independently of covariables [SE-IgE-high (0.35kU/L) vs. negative (<0.10kU/L) group: odds ratio 7.47, 95% confidence interval 1.86-30.03, P=0.005]. Multiple correspondence analyses also showed that high serum SE-IgE level had close relationships with severe asthma, CRS and sputum eosinophilia together. Conclusions and Clinical RelevanceThis is the first report on the significant associations of SE-IgE sensitization with late-onset asthma in the elderly, particularly severe eosinophilic asthma with CRS comorbidity. Our findings indicate a potential implication of SE in the high morbidity burden of elderly asthma and suggest clues to the pathogenesis of severe late-onset eosinophilic asthma in the elderly. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.title | Staphylococcal enterotoxin IgE sensitization in late-onset severe eosinophilic asthma in the elderly | - |
dc.type | Article | - |
dc.identifier.doi | 10.1111/cea.12652 | - |
dc.identifier.bibliographicCitation | CLINICAL AND EXPERIMENTAL ALLERGY, v.46, no.3, pp 411 - 421 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000371259100005 | - |
dc.identifier.scopusid | 2-s2.0-84959048332 | - |
dc.citation.endPage | 421 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 411 | - |
dc.citation.title | CLINICAL AND EXPERIMENTAL ALLERGY | - |
dc.citation.volume | 46 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | aged | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | enterotoxins | - |
dc.subject.keywordAuthor | eosinophils | - |
dc.subject.keywordAuthor | immunoglobulin E | - |
dc.subject.keywordAuthor | nasal polyps | - |
dc.subject.keywordAuthor | Staphylococcus aureus | - |
dc.subject.keywordPlus | CHRONIC RHINOSINUSITIS | - |
dc.subject.keywordPlus | AUREUS ENTEROTOXINS | - |
dc.subject.keywordPlus | POPULATION | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | PHENOTYPES | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | ADULTS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | EXACERBATIONS | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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