T resident helper cells promote humoral responses in the lung
DC Field | Value | Language |
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dc.contributor.author | Swarnalekha, Nivedya | - |
dc.contributor.author | Schreiner, David | - |
dc.contributor.author | Litzler, Ludivine C. | - |
dc.contributor.author | Iftikhar, Saadia | - |
dc.contributor.author | Kirchmeier, Daniel | - |
dc.contributor.author | Kunzli, Marco | - |
dc.contributor.author | Son, Young Min | - |
dc.contributor.author | Sun, Jie | - |
dc.contributor.author | Moreira, Etori Aguiar | - |
dc.contributor.author | King, Carolyn G. | - |
dc.date.accessioned | 2024-02-19T01:30:22Z | - |
dc.date.available | 2024-02-19T01:30:22Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 2470-9468 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72082 | - |
dc.description.abstract | Influenza is a deadly and costly infectious disease, even during flu seasons when an effective vaccine has been developed. To improve vaccines against respiratory viruses, a better understanding of the immune response at the site of infection is crucial. After influenza infection, clonally expanded T cells take up permanent residence in the lung, poised to rapidly respond to subsequent infection. Here, we characterized the dynamics and transcriptional regulation of lung-resident CD4(+) T cells during influenza infection and identified a long-lived, Bcl6-dependent population that we have termed T resident helper (T-RH) cells. T-RH cells arise in the lung independently of lymph node T follicular helper cells but are dependent on B cells, with which they tightly colocalize in inducible bronchus-associated lymphoid tissue (iBALT). Deletion of Bcl6 in CD4(+) T cells before heterotypic challenge infection resulted in redistribution of CD4(+) T cells outside of iBALT areas and impaired local antibody production. These results highlight iBALT as a homeostatic niche for T-RH cells and advocate for vaccination strategies that induce T-RH cells in the lung. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | T resident helper cells promote humoral responses in the lung | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/sciimmunol.abb6808 | - |
dc.identifier.bibliographicCitation | SCIENCE IMMUNOLOGY, v.6, no.55 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000606980300001 | - |
dc.identifier.scopusid | 2-s2.0-85099721913 | - |
dc.citation.number | 55 | - |
dc.citation.title | SCIENCE IMMUNOLOGY | - |
dc.citation.volume | 6 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | B-CELLS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR | - |
dc.subject.keywordPlus | ANTIGEN-BINDING | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | DISTINCT | - |
dc.subject.keywordPlus | VACCINE | - |
dc.subject.keywordPlus | BCL6 | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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