Tissue-resident CD8<SUP>+</SUP> T cells drive age-associated chronic lung sequelae after viral pneumonia
DC Field | Value | Language |
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dc.contributor.author | Goplen, Nick P. | - |
dc.contributor.author | Wu, Yue | - |
dc.contributor.author | Son, Young Min | - |
dc.contributor.author | Li, Chaofan | - |
dc.contributor.author | Wang, Zheng | - |
dc.contributor.author | Cheon, In Su | - |
dc.contributor.author | Jiang, Li | - |
dc.contributor.author | Zhu, Bibo | - |
dc.contributor.author | Ayasoufi, Katayoun | - |
dc.contributor.author | Chini, Eduardo N. | - |
dc.contributor.author | Johnson, Aaron J. | - |
dc.contributor.author | Vassallo, Robert | - |
dc.contributor.author | Limper, Andrew H. | - |
dc.contributor.author | Zhang, Nu | - |
dc.contributor.author | Sun, Jie | - |
dc.date.accessioned | 2024-02-19T01:30:23Z | - |
dc.date.available | 2024-02-19T01:30:23Z | - |
dc.date.issued | 2020-11 | - |
dc.identifier.issn | 2470-9468 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72083 | - |
dc.description.abstract | Lower respiratory viral infections, such as influenza virus and severe acute respiratory syndrome coronavirus 2 infections, often cause severe viral pneumonia in aged individuals. Here, we report that influenza viral pneumonia leads to chronic nonresolving lung pathology and exacerbated accumulation of CD8(+) tissue-resident memory T cells (T-RM) in the respiratory tract of aged hosts. T-RM cell accumulation relies on elevated TGF-beta present in aged tissues. Further, we show that T-RM cells isolated from aged lungs lack a subpopulation characterized by expression of molecules involved in TCR signaling and effector function. Consequently, T-RM cells from aged lungs were insufficient to provide heterologous protective immunity. The depletion of CD8(+) T-RM cells dampens persistent chronic lung inflammation and ameliorates tissue fibrosis in aged, but not young, animals. Collectively, our data demonstrate that age-associated T-RM cell malfunction supports chronic lung inflammatory and fibrotic sequelae after viral pneumonia. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Tissue-resident CD8<SUP>+</SUP> T cells drive age-associated chronic lung sequelae after viral pneumonia | - |
dc.type | Article | - |
dc.identifier.doi | 10.1126/sciimmunol.abc4557 | - |
dc.identifier.bibliographicCitation | SCIENCE IMMUNOLOGY, v.5, no.53 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000589837000002 | - |
dc.identifier.scopusid | 2-s2.0-85095802951 | - |
dc.citation.number | 53 | - |
dc.citation.title | SCIENCE IMMUNOLOGY | - |
dc.citation.volume | 5 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | INFLUENZA-A VIRUS | - |
dc.subject.keywordPlus | ANTIGEN PRESENTATION | - |
dc.subject.keywordPlus | MAINTENANCE | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | IMMUNODOMINANCE | - |
dc.subject.keywordPlus | ESTABLISHMENT | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordPlus | EXPANSION | - |
dc.subject.keywordPlus | DECLINE | - |
dc.subject.keywordPlus | BURDEN | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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