Lipoteichoic Acid Suppresses Effector T Cells Induced by <i>Staphylococcus aureus</i>-Pulsed Dendritic Cells
DC Field | Value | Language |
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dc.contributor.author | Son, Young Min | - |
dc.contributor.author | Song, Ki-Duk | - |
dc.contributor.author | Park, Sung-Moo | - |
dc.contributor.author | Han, Seung Hyun | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.date.accessioned | 2024-02-19T02:30:45Z | - |
dc.date.available | 2024-02-19T02:30:45Z | - |
dc.date.issued | 2013-07 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.issn | 1738-8872 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72119 | - |
dc.description.abstract | Lipoteichoic acid (LTA), uniquely expressed on gram-positive bacteria, is recognized by Toll-like receptor 2 (TLR2) on not only antigen-presenting cells but also activated T cells. Therefore, it is reasonable to assume that LTA is acting on T cells. However, little is known about the effect of LTA on T-cell regulation. In the present study, we investigated the immunomodulatory effects of LTA on CD4(+) T cells. Effector CD4(+) T cells, induced after co-culture with S. aureus-pulsed dendritic cells, produced high levels of interferon-gamma, CD25, CD69, and TLRs 2 and 4. When effector CD4(+) T cells were treated with LTA, the expressions of the membrane-bound form of transforming growth factor (TGF)-beta and forkhead box P3 increased. Coincidently, the proliferation of effector CD4(+) T cells was declined after LTA treatment. When TGF-beta signaling was blocked by the TGF-beta receptor 1 kinase inhibitor, LTA failed to suppress the proliferation of effector CD4(+) T cells. Therefore, the present results suggest that LTA suppresses the activity of effector CD4(+) T cells by enhancing TGF-beta production. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.title | Lipoteichoic Acid Suppresses Effector T Cells Induced by <i>Staphylococcus aureus</i>-Pulsed Dendritic Cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.4014/jmb.1302.02009 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.23, no.7, pp 1023 - 1030 | - |
dc.identifier.kciid | ART001790303 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000322502800016 | - |
dc.identifier.scopusid | 2-s2.0-84880670792 | - |
dc.citation.endPage | 1030 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1023 | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.volume | 23 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Lipoteichoic acid | - |
dc.subject.keywordAuthor | immune tolerance | - |
dc.subject.keywordAuthor | regulatory T cells | - |
dc.subject.keywordAuthor | effector CD4(+) T cells | - |
dc.subject.keywordAuthor | TGF-beta | - |
dc.subject.keywordPlus | TOLL-LIKE RECEPTOR-2 | - |
dc.subject.keywordPlus | GRAM-POSITIVE BACTERIA | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | TLR2 | - |
dc.subject.keywordPlus | RECOGNITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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