Curcumin Inhibits CD4<SUP>+</SUP> T Cell Activation, but Augments CD69 Expression and TGF-β1-Mediated Generation of Regulatory T Cells at Late Phase
DC Field | Value | Language |
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dc.contributor.author | Kim, Girak | - |
dc.contributor.author | Jang, Mi Seon | - |
dc.contributor.author | Son, Young Min | - |
dc.contributor.author | Seo, Min Ji | - |
dc.contributor.author | Ji, Sang Yun | - |
dc.contributor.author | Han, Seung Hyun | - |
dc.contributor.author | Jung, In Duk | - |
dc.contributor.author | Park, Yeong-Min | - |
dc.contributor.author | Jung, Hyun Jung | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.date.accessioned | 2024-02-19T02:30:47Z | - |
dc.date.available | 2024-02-19T02:30:47Z | - |
dc.date.issued | 2013-04 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72121 | - |
dc.description.abstract | Background: Curcumin is a promising candidate for a natural medicinal agent to treat chronic inflammatory diseases. Although CD4(+) T cells have been implicated in the pathogenesis of chronic inflammation, whether curcumin directly regulates CD4(+) T cells has not been definitively established. Here, we showed curcumin-mediated regulation of CD2/CD3/CD28-initiated CD4(+) T cell activation in vitro. Methodology/Principal Findings: Primary human CD4(+) T cells were stimulated with anti-CD2/CD3/CD28 antibody-coated beads as an in vitro surrogate system for antigen presenting cell-T cell interaction and treated with curcumin. We found that curcumin suppresses CD2/CD3/CD28-initiated CD4(+) T cell activation by inhibiting cell proliferation, differentiation and cytokine production. On the other hand, curcumin attenuated the spontaneous decline of CD69 expression and indirectly increased expression of CCR7, L-selectin and Transforming growth factor-beta 1 (TGF-beta 1) at the late phase of CD2/CD3/CD28-initiated T cell activation. Curcumin-mediated up-regulation of CD69 at late phase was associated with ERK1/2 signaling. Furthermore, TGF-beta 1 was involved in curcumin-mediated regulation of T cell activation and late-phase generation of regulatory T cells. Conclusions/Significance: Curcumin not merely blocks, but regulates CD2/CD3/CD28-initiated CD4(+) T cell activation by augmenting CD69, CCR7, L-selectin and TGF-beta 1 expression followed by regulatory T cell generation. These results suggest that curcumin could directly reduce T cell-dependent inflammatory stress by modulating CD4(+) T cell activation at multiple levels. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Curcumin Inhibits CD4<SUP>+</SUP> T Cell Activation, but Augments CD69 Expression and TGF-β1-Mediated Generation of Regulatory T Cells at Late Phase | - |
dc.type | Article | - |
dc.identifier.doi | 10.1371/journal.pone.0062300 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.8, no.4 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.wosid | 000318343700047 | - |
dc.identifier.scopusid | 2-s2.0-84876836568 | - |
dc.citation.number | 4 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 8 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | LYMPHOCYTE-PROLIFERATION | - |
dc.subject.keywordPlus | ANTIGEN CD69 | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | S1P(1) | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | AUTOIMMUNE | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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