Interactions of dendritic cells with cancer cells and modulation of surface molecules affect functional properties of CD8<SUP>+</SUP> T cells
DC Field | Value | Language |
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dc.contributor.author | Seo, Min Ji | - |
dc.contributor.author | Kim, Gi Rak | - |
dc.contributor.author | Yang, Deok-Chun | - |
dc.contributor.author | Chu, Hyuk | - |
dc.contributor.author | Min, Tae Sun | - |
dc.contributor.author | Son, Young Min | - |
dc.contributor.author | Jung, In Duk | - |
dc.contributor.author | Park, Yeong-Min | - |
dc.contributor.author | Han, Seung Hyun | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.date.accessioned | 2024-02-19T02:30:53Z | - |
dc.date.available | 2024-02-19T02:30:53Z | - |
dc.date.issued | 2011-09 | - |
dc.identifier.issn | 0161-5890 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72126 | - |
dc.description.abstract | To understand the interaction of dendritic cells (DCs) with cancer cells, we investigated molecular changes in DCs following co-culture with cancer cells. DCs co-cultured with Jurkat cancer cells showed remarkable down-regulation of MHC class I molecules, while DCs co-cultured with MCF-7 cancer cells showed minimal changes. Interestingly, down-regulation of MHC class Ion DCs was not observed upon treatment with Jurkat cell lysate or culture supernatant, suggesting the importance of direct cell-cell interactions. The expressions of CD40, CD80, CD83, MHC class II, and IL-12p40 on DCs co-cultured with Jurkat cells were only slightly affected. In contrast, DCs co-cultured with MCF-7 cells showed increased expressions of CD80, CD83, CD86, and IL-12p40. Furthermore, DCs co-cultured with Jurkat cells showed a down-regulation of low molecular weight polypeptides (LMP) 7, and of transporter associated with antigen processing (TAP) 1 and 2 at the mRNA expression level. LMP7, TAP2 and beta 2-microglobulin (beta 2M) were also down-regulated at the protein level. We further demonstrated how altered expression of MHC class I on DCs caused by co-culture with cancer cells affected autologous CD8(+) T cells, using the model MHC class l-presented HSV antigen. We found that DCs that had been HSV-treated and co-cultured with Jurkat cells showed a reduced potency to activate CD8(+) T cells. In contrast, HSV-treated DCs that had been co-cultured with MCF-7 cells induced activation of CD8(+) T cells, including high expression of CD25, CD69, granzyme B and cytokines, TNF-alpha and IFN-gamma. (C) 2011 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Interactions of dendritic cells with cancer cells and modulation of surface molecules affect functional properties of CD8<SUP>+</SUP> T cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.molimm.2011.04.018 | - |
dc.identifier.bibliographicCitation | MOLECULAR IMMUNOLOGY, v.48, no.15-16, pp 1744 - 1752 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000295395300002 | - |
dc.identifier.scopusid | 2-s2.0-80051921707 | - |
dc.citation.endPage | 1752 | - |
dc.citation.number | 15-16 | - |
dc.citation.startPage | 1744 | - |
dc.citation.title | MOLECULAR IMMUNOLOGY | - |
dc.citation.volume | 48 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Dendritic cells | - |
dc.subject.keywordAuthor | Cancer cells | - |
dc.subject.keywordAuthor | Major histocompatibility complex | - |
dc.subject.keywordAuthor | CD8(+) T cells | - |
dc.subject.keywordAuthor | Antigen processing component | - |
dc.subject.keywordPlus | MHC CLASS-I | - |
dc.subject.keywordPlus | ANTIGEN-PROCESSING MACHINERY | - |
dc.subject.keywordPlus | IMMUNE ESCAPE | - |
dc.subject.keywordPlus | MALIGNANT-CELLS | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | MATURATION | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | BLOOD | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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