Ginsenoside Re enhances survival of human CD4<SUP>+</SUP> T cells through regulation of autophagy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, Young Min | - |
dc.contributor.author | Kwak, Chae Won | - |
dc.contributor.author | Lee, Yeo Jin | - |
dc.contributor.author | Yang, Deok-Chun | - |
dc.contributor.author | Park, Byung-Chul | - |
dc.contributor.author | Lee, Woon Kyu | - |
dc.contributor.author | Han, Seung Hyun | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.date.accessioned | 2024-02-19T02:31:06Z | - |
dc.date.available | 2024-02-19T02:31:06Z | - |
dc.date.issued | 2010-05 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.issn | 1878-1705 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72139 | - |
dc.description.abstract | In the present study, we examined the effects of ginsenoside Re (Re) on cytokine expression, cytokine-dependent autophagy and cell survival in human CD4(+) T cells. When CD4(+) T cells isolated from human peripheral blood were treated with Re, LC3 and monodansylcadaverine (MDC), representative markers of autophagy, were decreased in a dose-dependent manner. Interestingly, Re suppressed the production of interferon-gamma (IFN-gamma) and immunity-related GTPase family M (IRGM) in CD4(+) T cells whereas no changes in other autophagy-related signaling molecules (ERK, p38 and AKT-mTOR-p70S6k) were found. Concomitantly, we observed that Re increased the proliferation of CD4(+) T cells with decreased cell death. Our results demonstrate that ginsenoside Re enhanced viability of CD4(+) T cells through the regulation of IFN-gamma-dependent autophagy activity. (C) 2010 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Ginsenoside Re enhances survival of human CD4<SUP>+</SUP> T cells through regulation of autophagy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.intimp.2010.03.002 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL IMMUNOPHARMACOLOGY, v.10, no.5, pp 626 - 631 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000277852700012 | - |
dc.identifier.scopusid | 2-s2.0-77950612286 | - |
dc.citation.endPage | 631 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 626 | - |
dc.citation.title | INTERNATIONAL IMMUNOPHARMACOLOGY | - |
dc.citation.volume | 10 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Ginsenoside Re | - |
dc.subject.keywordAuthor | CD4(+) T cells | - |
dc.subject.keywordAuthor | Autophagy | - |
dc.subject.keywordAuthor | Interferon related GTPase family M | - |
dc.subject.keywordAuthor | Interferon-gamma | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | RH2 | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.