Synergistic production of interleukin-23 by dendritic cells derived from cord blood in response to costimulation with LPS and IL-12
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Mi Seon | - |
dc.contributor.author | Son, Young Min | - |
dc.contributor.author | Kim, Gi Rak | - |
dc.contributor.author | Lee, Yeo Jin | - |
dc.contributor.author | Lee, Woon Kyu | - |
dc.contributor.author | Cha, Seok Ho | - |
dc.contributor.author | Han, Seung Hyun | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.date.accessioned | 2024-02-19T02:31:07Z | - |
dc.date.available | 2024-02-19T02:31:07Z | - |
dc.date.issued | 2009-09 | - |
dc.identifier.issn | 0741-5400 | - |
dc.identifier.issn | 1938-3673 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72140 | - |
dc.description.abstract | This study was performed to provide insight for the optimization and regulation of immune homeostasis, which should be taken into account in the development of cell therapy using DCs and/or cytokine. Human CBDCs costimulated with LPS and IL-12 were examined for cytokine expression compared with ABDCs. Our results showed that costimulation with IL-12 and LPS in CBDCs resulted in increased expression of IL-23. Concomitantly, the phosphorylation of ERKs and p38 MAPK was increased, suggesting that these kinases are important signaling components for IL-23 induction in CBDC costimulated with LPS and IL-12. Furthermore, production of IL-23 in CBDC costimulated with LPS and IL-12 caused CD4(+) CD45RO(+) memory cells to increase IFN-gamma production. Taken together, CBDCs, costimulated with LPS and IL-12, show a synergistic increase in IL-23 production via enhanced phosphorylation of ERK1/2 and p38 MAPK and consequently, an induction of IFN-gamma production in the memory cells. J. Leukoc. Biol. 86: 691-699; 2009. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | FEDERATION AMER SOC EXP BIOL | - |
dc.title | Synergistic production of interleukin-23 by dendritic cells derived from cord blood in response to costimulation with LPS and IL-12 | - |
dc.type | Article | - |
dc.identifier.doi | 10.1189/jlb.1008639 | - |
dc.identifier.bibliographicCitation | JOURNAL OF LEUKOCYTE BIOLOGY, v.86, no.3, pp 691 - 699 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000269377200028 | - |
dc.identifier.scopusid | 2-s2.0-70149123009 | - |
dc.citation.endPage | 699 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 691 | - |
dc.citation.title | JOURNAL OF LEUKOCYTE BIOLOGY | - |
dc.citation.volume | 86 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | human | - |
dc.subject.keywordAuthor | antigen-presenting cells | - |
dc.subject.keywordAuthor | cytokines | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | AUTOIMMUNE INFLAMMATION | - |
dc.subject.keywordPlus | ADAPTIVE IMMUNITY | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | DIVERGENT ROLES | - |
dc.subject.keywordPlus | HOST-DEFENSE | - |
dc.subject.keywordPlus | IL-23 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INNATE | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
84, Heukseok-ro, Dongjak-gu, Seoul, Republic of Korea (06974)02-820-6194
COPYRIGHT 2019 Chung-Ang University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.