Curcumin attenuates decline of CD69 expression on CD4+T cells and induces generation of CD25hiFoxp3+T cells through TGF-β1 production
DC Field | Value | Language |
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dc.contributor.author | Kim, Gi Rak | - |
dc.contributor.author | Jang, Mi Seon | - |
dc.contributor.author | Son, Young Min | - |
dc.contributor.author | Han, Seung Hyun | - |
dc.contributor.author | Yun, Cheol-Heui | - |
dc.date.accessioned | 2024-02-19T05:00:23Z | - |
dc.date.available | 2024-02-19T05:00:23Z | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.issn | 1550-6606 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72155 | - |
dc.description.abstract | Curcumin is a promising candidate as a natural medicinal agent to treat chronic inflammatory diseases. However, little is known about curcumin-mediated CD4+ T cell regulation, which contributes to the therapeutic effects of curcumin. Here, we report that curcumin inhibits T-cell receptor (TCR)-triggered immune responses of CD4+ T cells through suppression of proliferation, cytokine production and differentiation of CD4+ T cells. Intriguingly, spontaneous decline of CD69 expression was attenuated by curcumin treatment, which continued until 6 days of culture. We showed that curcumin-mediated CD69 up-regulation was dependent on extracellular signal-regulated kinase 1/2 (ERK1/2) signaling. Concomitantly, the expressions of C-C motif chemokine receptor 7 (CCR7), L-selectin and transforming growth factor-β1 (TGF-β1) were also increased. TGF-β1 production was moderate, but was high enough to lead to the late generation of CD25hiFoxp3+CD4+ T cells and to maintain prolonged suppression of CD4+ T cell activation. These findings suggest that the immunoregulatory role of curcumin is effective for CD4+ T cells. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.title | Curcumin attenuates decline of CD69 expression on CD4+T cells and induces generation of CD25hiFoxp3+T cells through TGF-β1 production | - |
dc.type | Article | - |
dc.identifier.doi | 10.4049/jimmunol.186.Supp.152.22 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, v.186 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 000209751706072 | - |
dc.citation.title | JOURNAL OF IMMUNOLOGY | - |
dc.citation.volume | 186 | - |
dc.type.docType | Meeting Abstract | - |
dc.publisher.location | 미국 | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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