Statistical optimization of environmental factors to produce the cytotoxic enniatins H, I and MK1688 against human multidrug resistance cancer cell lines
DC Field | Value | Language |
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dc.contributor.author | Hwang, YoungMin | - |
dc.contributor.author | Lee, Hee-Seok | - |
dc.date.accessioned | 2024-02-29T01:00:32Z | - |
dc.date.available | 2024-02-29T01:00:32Z | - |
dc.date.issued | 2024-02 | - |
dc.identifier.issn | 1226-7708 | - |
dc.identifier.issn | 2092-6456 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72561 | - |
dc.description.abstract | The environmental conditions were optimized to produce the enniatin H, I, and MK1688 by Fusarium strain on cereal grain exhibiting anti-carcinogenic potential against MES-SA (human uterine sarcoma cell line), HCT15 (human colorectal carcinoma cancer cell line), and their multidrug resistance sublines. From the statistical optimization by response surface methodology, the optimal condition of independent variables affecting the response variables were 20.85 °C (temperature), 46.85% (w/w, initial moisture content), and 18.42 days (growth time) for ENN H; 23.31 °C, 44.15% (w/w) and 17.23 days for ENN I; 23.08 °C, 43.97% (w/w) and 17.06 days for ENN MK1688. In case of cytotoxic effects, ENNs significantly suppressed growth of cancer cell lines without multidrug resistance, and ENN I inhibited growth of cancer cell lines most strongly. These data will provide valuable point to produce the cyclic hexadepsipeptide exhibiting anti-carcinogenic potential from Fusarium strains. © 2023, The Korean Society of Food Science and Technology. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | The Korean Society of Food Science and Technology | - |
dc.title | Statistical optimization of environmental factors to produce the cytotoxic enniatins H, I and MK1688 against human multidrug resistance cancer cell lines | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s10068-023-01363-5 | - |
dc.identifier.bibliographicCitation | Food Science and Biotechnology, v.33, no.3, pp 579 - 587 | - |
dc.identifier.kciid | ART003046186 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001038858300001 | - |
dc.identifier.scopusid | 2-s2.0-85166354899 | - |
dc.citation.endPage | 587 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 579 | - |
dc.citation.title | Food Science and Biotechnology | - |
dc.citation.volume | 33 | - |
dc.type.docType | Article | - |
dc.publisher.location | 대한민국 | - |
dc.subject.keywordAuthor | Culture condition | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Enniatin | - |
dc.subject.keywordAuthor | Multidrug resistance | - |
dc.subject.keywordAuthor | Response surface methodology | - |
dc.subject.keywordPlus | FUNGUS VERTICILLIUM-HEMIPTERIGENUM | - |
dc.subject.keywordPlus | FUSARIUM | - |
dc.subject.keywordPlus | BEAUVERICIN | - |
dc.subject.keywordPlus | MONILIFORMIN | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CULTURE | - |
dc.subject.keywordPlus | A(1) | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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