Effect of tuberculosis preventive treatment on household contacts of rifampin-resistant tuberculosis patients: A nationwide investigation
DC Field | Value | Language |
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dc.contributor.author | Gu, Kang-Mo | - |
dc.contributor.author | Jung, Sun-Young | - |
dc.contributor.author | Lee, Jae-Eun | - |
dc.contributor.author | Eom, Joo-Hyeon | - |
dc.contributor.author | Lee, Kyungeun | - |
dc.contributor.author | Park, Yong-Joon | - |
dc.contributor.author | Kwon, Yunhyung | - |
dc.contributor.author | Kim, Youmi | - |
dc.contributor.author | Choi, Jae Chol | - |
dc.date.accessioned | 2024-03-07T00:30:32Z | - |
dc.date.available | 2024-03-07T00:30:32Z | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 0903-1936 | - |
dc.identifier.issn | 1399-3003 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72676 | - |
dc.description.abstract | Background: South Korea is an intermediate TB burden country with a high incidence rate of rifampin-resistant TB (RR-TB). The effect of tuberculosis (TB) preventive treatment (TPT) on household contacts (HHC) of RR-TB in an intermediate TB burden country has not been well evaluated.Study Design and Methods: This retrospective cohort study analyzed data of HHC investigations from January 2015 to December 2018 in a linked database of the nationwide TB registry and healthcare administrative database of South Korea. The primary outcome was a risk of active TB in HHCs of RR-TB patients following tuberculosis preventive treatment.Results: Out of 82,783 HHCs with data on drug resistance patterns of the index case, 2,593 (4.6%) were in contact with RR-TB patients. Of these 2,593 RR-TB HHCs, 926 (35.7%) were confirmed to have latent TB infection. Among 926 of LTBI patients, 294 (31.7%) had initiated conventional TPT including isoniazid or rifampin, and 168 (57.1%) had completed it. There was no significant difference in the risk of active TB between the TPT complete group and the LTBI-negative group (aHR, 2.27 [95% CI, 0.58-8.83]). In terms of drug resistance profile concordance, 58.7% of the RR-TB HHCs had a concordant drug resistance pattern with the index cases.Conclusion: TB preventive treatment regimens including isoniazid or rifampin effectively prevent TB in household contacts of RR-TB in an intermediate TB burden country. Nationwide HHC investigation combined with TPT may be an effective strategy in reducing TB transmission in intermittent TB burden countries. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | EUROPEAN RESPIRATORY SOC JOURNALS LTD | - |
dc.title | Effect of tuberculosis preventive treatment on household contacts of rifampin-resistant tuberculosis patients: A nationwide investigation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1183/13993003.congress-2023.PA4536 | - |
dc.identifier.bibliographicCitation | EUROPEAN RESPIRATORY JOURNAL, v.62, no.S67 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001109120508011 | - |
dc.citation.number | S67 | - |
dc.citation.title | EUROPEAN RESPIRATORY JOURNAL | - |
dc.citation.volume | 62 | - |
dc.type.docType | Meeting Abstract | - |
dc.publisher.location | 영국 | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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