IL-38 alleviates atherogenic responses via SIRT6/HO-1 signaling: A promising strategy against obesity-related atherosclerosis
DC Field | Value | Language |
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dc.contributor.author | Cho, Wonjun | - |
dc.contributor.author | Oh, Heeseung | - |
dc.contributor.author | Abd El-Aty, A.M. | - |
dc.contributor.author | Mobarak, Enas H. | - |
dc.contributor.author | Jeong, Ji Hoon | - |
dc.contributor.author | Jung, Tae Woo | - |
dc.date.accessioned | 2024-03-07T02:05:10Z | - |
dc.date.available | 2024-03-07T02:05:10Z | - |
dc.date.issued | 2024-01 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72684 | - |
dc.description.abstract | Interleukin-38 (IL-38), a member of the IL-1 family, is known for its anti-inflammatory properties mediated through ligand signaling in various disease models. It plays a significant role in atherosclerosis development, forming a theoretical basis for therapeutic strategies. However, the direct effects of IL-38 on atherogenic responses in the vascular endothelium and monocytes remain unclear. In this investigation, IL-38 treatment reduced THP-1 monocyte adhesion to HUVECs, decreased the expression of vascular adhesion molecules, and mitigated inflammation in the presence of palmitate. IL-38 treatment upregulated SIRT6 expression and enhanced autophagy markers such as LC3 conversion and p62 degradation. The effects of IL-38 were nullified by siRNA-mediated suppression of SIRT6 or heme oxygenase-1 (HO-1) in HUVECs and palmitate-treated THP-1 cells. These findings reveal that IL-38 mitigates inflammation through the SIRT6/HO-1 pathway, offering a potential therapeutic approach for addressing obesity-related atherosclerosis. © 2023 Elsevier Inc. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier B.V. | - |
dc.title | IL-38 alleviates atherogenic responses via SIRT6/HO-1 signaling: A promising strategy against obesity-related atherosclerosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bbrc.2023.149407 | - |
dc.identifier.bibliographicCitation | Biochemical and Biophysical Research Communications, v.694 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001165704300001 | - |
dc.identifier.scopusid | 2-s2.0-85180952373 | - |
dc.citation.title | Biochemical and Biophysical Research Communications | - |
dc.citation.volume | 694 | - |
dc.type.docType | Article | - |
dc.publisher.location | 미국 | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | HO-1 | - |
dc.subject.keywordAuthor | HUVEC | - |
dc.subject.keywordAuthor | IL-38 | - |
dc.subject.keywordAuthor | SIRT6 | - |
dc.subject.keywordAuthor | THP-1 | - |
dc.subject.keywordPlus | HEME OXYGENASE-1 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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