Calcium carbonate particle platform for chemodynamic and self-luminescent photodynamic combination antibacterial therapy
DC Field | Value | Language |
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dc.contributor.author | Song, Yeong Jun | - |
dc.contributor.author | Kim, Jin Ju | - |
dc.contributor.author | Sul, Woo Jun | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.date.accessioned | 2024-03-13T02:00:36Z | - |
dc.date.available | 2024-03-13T02:00:36Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 2213-3437 | - |
dc.identifier.issn | 2213-2929 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/72791 | - |
dc.description.abstract | The abuse of antibiotics increases antibiotic-resistant bacteria and leads to the ineffectiveness of conventional antibiotics. Therefore, the development of alternative therapeutic strategies for combating antibiotics-resistant bacteria is challenging. In this study, calcium carbonate (CaCO3) was synthesised to load L-012 [chemiluminescence (CL) agent] and Ce6 (photosensitiser), and then, Co2+ (catalyst) doping was performed, yielding the Co@CaCO3/L-012/Ce6 particle system. The Co@CaCO3/L-012/Ce6 particles were exposed to the bacterial infection microenvironment (IME) under low pH and high levels of H2O2, and Co2+, L-012 and Ce6 were released in response to the acidic environment. The released Co2+ decomposed H2O2 to hydroxyl radicals (·OH) via Co2+-mediated chemodynamic therapy (CDT). Simultaneously, the produced ·OH reacted with L-012, which induced self-CL illumination as an excitation light source. Subsequently, the self-CL illumination activated Ce6 and generated the singlet oxygen (1O2). The enhanced production of ·OH and 1O2 through Co2+-mediated CDT and self-CL illumination-mediated Ce6-induced photodynamic therapy (self-PDT) effectively destroyed the integrity of Staphylococcus aureus (S. aureus) as well as Escherichia coli (E. coli), leading to the induction of the efficient apoptosis of the bacteria. Therefore, the dual-mode CDT/self-PDT system of Co@CaCO3/L-012/Ce6 particles will be an alternative strategy for antibacterial therapy. © 2024 Elsevier Ltd | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier Ltd | - |
dc.title | Calcium carbonate particle platform for chemodynamic and self-luminescent photodynamic combination antibacterial therapy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.jece.2024.111987 | - |
dc.identifier.bibliographicCitation | Journal of Environmental Chemical Engineering, v.12, no.2 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001172964400001 | - |
dc.identifier.scopusid | 2-s2.0-85183151628 | - |
dc.citation.number | 2 | - |
dc.citation.title | Journal of Environmental Chemical Engineering | - |
dc.citation.volume | 12 | - |
dc.type.docType | Article | - |
dc.publisher.location | 영국 | - |
dc.subject.keywordAuthor | Antibacterial therapy | - |
dc.subject.keywordAuthor | Chemodynamic therapy | - |
dc.subject.keywordAuthor | Chlorin e6 | - |
dc.subject.keywordAuthor | Fenton-like reaction | - |
dc.subject.keywordAuthor | L-012 | - |
dc.subject.keywordAuthor | Self-photodynamic therapy | - |
dc.subject.keywordPlus | CHEMILUMINESCENCE | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | ANTICANCER | - |
dc.subject.keywordPlus | BACTERIA | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | OXYGEN | - |
dc.subject.keywordPlus | CACO3 | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalWebOfScienceCategory | Engineering, Environmental | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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