Macrophage-mannose-receptor-targeted photoactivatable agent for in vivo imaging and treatment of atherosclerosis
DC Field | Value | Language |
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dc.contributor.author | Lee, Seung-Yul | - |
dc.contributor.author | Kim, Jin Hyuk | - |
dc.contributor.author | Song, Joon Woo | - |
dc.contributor.author | Min, Ji Seon | - |
dc.contributor.author | Kim, Hyun Jung | - |
dc.contributor.author | Kim, Ryeong Hyun | - |
dc.contributor.author | Ahn, Jae Won | - |
dc.contributor.author | Yoo, Hongki | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Kim, Jin Won | - |
dc.date.accessioned | 2024-03-25T07:00:28Z | - |
dc.date.available | 2024-03-25T07:00:28Z | - |
dc.date.issued | 2024-04 | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.issn | 1873-3476 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/cau/handle/2019.sw.cau/73007 | - |
dc.description.abstract | Previous studies have demonstrated the effects of theranostic agents on atherosclerotic plaques. However, there is limited information on targeted theranostics for photodynamic treatment of atherosclerosis. This study aimed to develop a macrophage-mannose-receptor-targeted photoactivatable nanoagent that regulates atherosclerosis and to evaluate its efficacy as well as safety in atherosclerotic mice. We synthesised and characterised D-mannosamine (MAN)-polyethylene glycol (PEG)-chlorin e6 (Ce6) for phototheranostic treatment of atherosclerosis. The diagnostic and therapeutic effects of MAN-PEG-Ce6 were investigated using the atherosclerotic mouse model. The hydrophobic Ce6 photosensitiser was surrounded by the hydrophilic MAN-PEG outer shell of the self-assembled nanostructure under aqueous conditions. The MAN-PEG-Ce6 was specifically internalised in macrophage-derived foam cells through receptor-mediated endocytosis. After laser irradiation, the MAN-PEG-Ce6 markedly increased singlet oxygen generation. Intravital imaging and immunohistochemistry analyses verified MAN-PEG-Ce6′s specificity to plaque macrophages and its notable anti-inflammatory impact by effectively reducing mannose-receptor-positive macrophages. The toxicity assay showed that MAN-PEG-Ce6 had negligible effects on the biochemical profile and structural damage in the skin and organs. Targeted photoactivation with MAN-PEG-Ce6 thus has the potential to rapidly reduce macrophage-derived inflammatory responses in atheroma and present favourable toxicity profiles, making it a promising approach for both imaging and treatment of atherosclerosis. © 2024 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier B.V. | - |
dc.title | Macrophage-mannose-receptor-targeted photoactivatable agent for in vivo imaging and treatment of atherosclerosis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ijpharm.2024.123951 | - |
dc.identifier.bibliographicCitation | International Journal of Pharmaceutics, v.654 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.wosid | 001200025900001 | - |
dc.identifier.scopusid | 2-s2.0-85186573671 | - |
dc.citation.title | International Journal of Pharmaceutics | - |
dc.citation.volume | 654 | - |
dc.type.docType | Article | - |
dc.publisher.location | 네델란드 | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordAuthor | Chlorin e6 | - |
dc.subject.keywordAuthor | Macrophage | - |
dc.subject.keywordAuthor | Photodynamic therapy | - |
dc.subject.keywordAuthor | Photosensitiser | - |
dc.subject.keywordAuthor | Theranostics | - |
dc.subject.keywordPlus | HIGH-RISK PLAQUES | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | INDOCYANINE GREEN | - |
dc.subject.keywordPlus | ATHEROMAS | - |
dc.subject.keywordPlus | CATHETER | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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